Table 3

Multivariable analysis of OS from diagnosis and EFS from HSCT

PRelative risk (95% CI)
OS from diagnosis   
LIN28B   
  High .180 1.8 (0.8-4.2) 
  Low   
 Age at diagnosis, y   
  ≥2 .040 2.1 (1.0-4.2) 
  <2   
 Karyotype   
  Monosomy 7 .027 2.6 (1.1-6.2) 
  Normal   
 Mutation .814  
 Mutation (1)   
  PTPN11 .557 1.3 (0.6-2.9) 
  Other karyotypes   
 Mutation (2)   
  PTPN11 .631 1.3 (0.5-3.5) 
  Quadruple negative   
EFS from HSCT   
LIN28B   
  High .149 1.9 (0.8-4.5) 
  Low   
 Age at diagnosis, y   
  ≥2 .035 2.1 (1.1-4.2) 
  <2   
 Karyotype   
  Monosomy 7 .033 2.7 (1.1-6.6) 
  Normal   
 Mutation .305  
 Mutation (1)   
  PTPN11 .123 1.9 (0.8-4.3) 
  Other mutations   
 Mutation (2)   
  PTPN11 .554 1.3 (0.5-3.3) 
  Quadruple negative   
PRelative risk (95% CI)
OS from diagnosis   
LIN28B   
  High .180 1.8 (0.8-4.2) 
  Low   
 Age at diagnosis, y   
  ≥2 .040 2.1 (1.0-4.2) 
  <2   
 Karyotype   
  Monosomy 7 .027 2.6 (1.1-6.2) 
  Normal   
 Mutation .814  
 Mutation (1)   
  PTPN11 .557 1.3 (0.6-2.9) 
  Other karyotypes   
 Mutation (2)   
  PTPN11 .631 1.3 (0.5-3.5) 
  Quadruple negative   
EFS from HSCT   
LIN28B   
  High .149 1.9 (0.8-4.5) 
  Low   
 Age at diagnosis, y   
  ≥2 .035 2.1 (1.1-4.2) 
  <2   
 Karyotype   
  Monosomy 7 .033 2.7 (1.1-6.6) 
  Normal   
 Mutation .305  
 Mutation (1)   
  PTPN11 .123 1.9 (0.8-4.3) 
  Other mutations   
 Mutation (2)   
  PTPN11 .554 1.3 (0.5-3.3) 
  Quadruple negative   
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