Adverse events
Patient . | Grade 4* . | Grade 3 . | Grade 2 . |
---|---|---|---|
1 | White blood cell decreased | Hypophosphatemia | Nausea |
Neutrophil count decreased | Anemia | Headache | |
Hypocalcemia | |||
2 | White blood cell decreased | Anemia | Nausea |
Neutrophil count decreased | Upper respiratory infection | ||
Platelet count decreased | |||
3 | White blood cell decreased | Anemia | |
Neutrophil count decreased | |||
Platelet count decreased | |||
4 | White blood cell decreased | Nausea | |
Hypophosphatemia | Hypocalcemia | ||
Neutrophil count decreased | Fever | ||
Atrial fibrillation | |||
Anemia | |||
Thromboembolic event | |||
5 | White blood cell decreased | aPTT increased | Fever |
Neutrophil count decreased | Platelet count decreased | ||
6 | White blood cell decreased | Hyponatremia | Nausea, vomiting |
Neutrophil count decreased | Anemia | ||
7 | White blood cell decreased | Anemia | |
Neutrophil count decreased | |||
8 | White blood cell decreased | Anemia | Rash, maculopapular |
Neutrophil count decreased | Fever | Sinus tachycardia | |
Platelet count decreased | Hypophosphatemia | Dyspnea | |
Febrile neutropenia | ALT increased | ||
Hypotension | Hypoalbuminemia, hypocalcemia | ||
9 | White blood cell decreased | Hypophosphatemia | Anorexia |
Neutrophil count decreased | Nausea, vomiting | ||
Creatine phosphokinase increased† | Anemia | ||
Diarrhea Upper respiratory infection | |||
10 | White blood cell decreased | Fever | Hypomagnesemia |
Neutrophil count decreased | Anemia | aPTT | |
Platelet count decreased | Sinus tachycardia | Delirium | |
Creatine phosphokinase increased | Dyspnea | Hypoalbuminemia | |
Hypotension | Febrile neutropenia | ALT increased | |
Catheter-related infection | Urinary tract infection | Hypocalcemia | |
Sepsis | Hypophosphatemia | Creatinine increased | |
Hypoxia | Blood bilirubin increased | ||
Acute kidney injury | Abdominal distention | ||
AST increased | Thromboembolic event | ||
Alkalosis | |||
Hyperuricemia | |||
Muscle weakness | |||
Hypokalemia | |||
11 | White blood cell decreased | Anemia | Hypoalbuminemia |
Neutrophil count decreased | Fever | Epistaxis | |
Platelet count decreased | Delirium | Acute kidney injury | |
Sinus tachycardia | Creatinine increased | ||
Hypotension | Hypocalcemia | ||
Blood bilirubin increased | |||
Hypoxia | |||
Hypermagnesemia | |||
Dyspnea | |||
Hypernatremia | |||
Cardiac troponin increased | |||
Fibrinogen decreased | |||
Anemia | |||
Hypophosphatemia | |||
Creatine phosphokinase increased | |||
Hypertension AST increased | |||
12 | White blood cell decreased | Platelet count decreased | Fever |
Neutrophil count decreased | Anemia |
Patient . | Grade 4* . | Grade 3 . | Grade 2 . |
---|---|---|---|
1 | White blood cell decreased | Hypophosphatemia | Nausea |
Neutrophil count decreased | Anemia | Headache | |
Hypocalcemia | |||
2 | White blood cell decreased | Anemia | Nausea |
Neutrophil count decreased | Upper respiratory infection | ||
Platelet count decreased | |||
3 | White blood cell decreased | Anemia | |
Neutrophil count decreased | |||
Platelet count decreased | |||
4 | White blood cell decreased | Nausea | |
Hypophosphatemia | Hypocalcemia | ||
Neutrophil count decreased | Fever | ||
Atrial fibrillation | |||
Anemia | |||
Thromboembolic event | |||
5 | White blood cell decreased | aPTT increased | Fever |
Neutrophil count decreased | Platelet count decreased | ||
6 | White blood cell decreased | Hyponatremia | Nausea, vomiting |
Neutrophil count decreased | Anemia | ||
7 | White blood cell decreased | Anemia | |
Neutrophil count decreased | |||
8 | White blood cell decreased | Anemia | Rash, maculopapular |
Neutrophil count decreased | Fever | Sinus tachycardia | |
Platelet count decreased | Hypophosphatemia | Dyspnea | |
Febrile neutropenia | ALT increased | ||
Hypotension | Hypoalbuminemia, hypocalcemia | ||
9 | White blood cell decreased | Hypophosphatemia | Anorexia |
Neutrophil count decreased | Nausea, vomiting | ||
Creatine phosphokinase increased† | Anemia | ||
Diarrhea Upper respiratory infection | |||
10 | White blood cell decreased | Fever | Hypomagnesemia |
Neutrophil count decreased | Anemia | aPTT | |
Platelet count decreased | Sinus tachycardia | Delirium | |
Creatine phosphokinase increased | Dyspnea | Hypoalbuminemia | |
Hypotension | Febrile neutropenia | ALT increased | |
Catheter-related infection | Urinary tract infection | Hypocalcemia | |
Sepsis | Hypophosphatemia | Creatinine increased | |
Hypoxia | Blood bilirubin increased | ||
Acute kidney injury | Abdominal distention | ||
AST increased | Thromboembolic event | ||
Alkalosis | |||
Hyperuricemia | |||
Muscle weakness | |||
Hypokalemia | |||
11 | White blood cell decreased | Anemia | Hypoalbuminemia |
Neutrophil count decreased | Fever | Epistaxis | |
Platelet count decreased | Delirium | Acute kidney injury | |
Sinus tachycardia | Creatinine increased | ||
Hypotension | Hypocalcemia | ||
Blood bilirubin increased | |||
Hypoxia | |||
Hypermagnesemia | |||
Dyspnea | |||
Hypernatremia | |||
Cardiac troponin increased | |||
Fibrinogen decreased | |||
Anemia | |||
Hypophosphatemia | |||
Creatine phosphokinase increased | |||
Hypertension AST increased | |||
12 | White blood cell decreased | Platelet count decreased | Fever |
Neutrophil count decreased | Anemia |
Adverse event terms from the Common Toxicity Criteria for Adverse Events version 4.02 were used for adverse event grading for this trial, and these terms are used in this table; all greater than grade 1 adverse events are listed regardless of attribution. ALT, alanine amino transferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase.
All patients had grade 4 lymphocyte count decreased, which was expected after the chemotherapy conditioning regimen that the patients received. Lymphocyte count decreased was not listed repetitively for each patient.
Creatine phosphokinase elevation in this patient was almost certainly caused by exercise.