Table 2

Adverse events

PatientGrade 4*Grade 3Grade 2
White blood cell decreased Hypophosphatemia Nausea 
Neutrophil count decreased Anemia Headache 
Hypocalcemia 
White blood cell decreased Anemia Nausea 
Neutrophil count decreased Upper respiratory infection 
Platelet count decreased 
White blood cell decreased Anemia  
Neutrophil count decreased 
Platelet count decreased 
 White blood cell decreased Nausea 
Hypophosphatemia Hypocalcemia 
Neutrophil count decreased Fever 
 Atrial fibrillation 
 Anemia 
 Thromboembolic event 
White blood cell decreased aPTT increased Fever 
Neutrophil count decreased Platelet count decreased 
White blood cell decreased Hyponatremia Nausea, vomiting 
Neutrophil count decreased Anemia 
White blood cell decreased  Anemia 
Neutrophil count decreased 
White blood cell decreased Anemia Rash, maculopapular 
Neutrophil count decreased Fever Sinus tachycardia 
Platelet count decreased Hypophosphatemia Dyspnea 
 Febrile neutropenia ALT increased 
 Hypotension Hypoalbuminemia, hypocalcemia 
White blood cell decreased Hypophosphatemia Anorexia 
Neutrophil count decreased Nausea, vomiting 
Creatine phosphokinase increased Anemia 
 Diarrhea Upper respiratory infection 
10 White blood cell decreased Fever Hypomagnesemia 
Neutrophil count decreased Anemia aPTT 
Platelet count decreased Sinus tachycardia Delirium 
Creatine phosphokinase increased Dyspnea Hypoalbuminemia 
Hypotension Febrile neutropenia ALT increased 
Catheter-related infection Urinary tract infection Hypocalcemia 
Sepsis Hypophosphatemia Creatinine increased 
 Hypoxia Blood bilirubin increased 
 Acute kidney injury Abdominal distention 
 AST increased Thromboembolic event 
 Alkalosis  
 Hyperuricemia  
 Muscle weakness  
 Hypokalemia  
11 White blood cell decreased Anemia Hypoalbuminemia 
Neutrophil count decreased Fever Epistaxis 
Platelet count decreased Delirium Acute kidney injury 
 Sinus tachycardia Creatinine increased 
 Hypotension Hypocalcemia 
 Blood bilirubin increased  
 Hypoxia  
 Hypermagnesemia  
 Dyspnea  
 Hypernatremia  
 Cardiac troponin increased  
 Fibrinogen decreased  
 Anemia  
 Hypophosphatemia  
 Creatine phosphokinase increased  
 Hypertension AST increased  
12 White blood cell decreased Platelet count decreased Fever 
Neutrophil count decreased Anemia 
PatientGrade 4*Grade 3Grade 2
White blood cell decreased Hypophosphatemia Nausea 
Neutrophil count decreased Anemia Headache 
Hypocalcemia 
White blood cell decreased Anemia Nausea 
Neutrophil count decreased Upper respiratory infection 
Platelet count decreased 
White blood cell decreased Anemia  
Neutrophil count decreased 
Platelet count decreased 
 White blood cell decreased Nausea 
Hypophosphatemia Hypocalcemia 
Neutrophil count decreased Fever 
 Atrial fibrillation 
 Anemia 
 Thromboembolic event 
White blood cell decreased aPTT increased Fever 
Neutrophil count decreased Platelet count decreased 
White blood cell decreased Hyponatremia Nausea, vomiting 
Neutrophil count decreased Anemia 
White blood cell decreased  Anemia 
Neutrophil count decreased 
White blood cell decreased Anemia Rash, maculopapular 
Neutrophil count decreased Fever Sinus tachycardia 
Platelet count decreased Hypophosphatemia Dyspnea 
 Febrile neutropenia ALT increased 
 Hypotension Hypoalbuminemia, hypocalcemia 
White blood cell decreased Hypophosphatemia Anorexia 
Neutrophil count decreased Nausea, vomiting 
Creatine phosphokinase increased Anemia 
 Diarrhea Upper respiratory infection 
10 White blood cell decreased Fever Hypomagnesemia 
Neutrophil count decreased Anemia aPTT 
Platelet count decreased Sinus tachycardia Delirium 
Creatine phosphokinase increased Dyspnea Hypoalbuminemia 
Hypotension Febrile neutropenia ALT increased 
Catheter-related infection Urinary tract infection Hypocalcemia 
Sepsis Hypophosphatemia Creatinine increased 
 Hypoxia Blood bilirubin increased 
 Acute kidney injury Abdominal distention 
 AST increased Thromboembolic event 
 Alkalosis  
 Hyperuricemia  
 Muscle weakness  
 Hypokalemia  
11 White blood cell decreased Anemia Hypoalbuminemia 
Neutrophil count decreased Fever Epistaxis 
Platelet count decreased Delirium Acute kidney injury 
 Sinus tachycardia Creatinine increased 
 Hypotension Hypocalcemia 
 Blood bilirubin increased  
 Hypoxia  
 Hypermagnesemia  
 Dyspnea  
 Hypernatremia  
 Cardiac troponin increased  
 Fibrinogen decreased  
 Anemia  
 Hypophosphatemia  
 Creatine phosphokinase increased  
 Hypertension AST increased  
12 White blood cell decreased Platelet count decreased Fever 
Neutrophil count decreased Anemia 

Adverse event terms from the Common Toxicity Criteria for Adverse Events version 4.02 were used for adverse event grading for this trial, and these terms are used in this table; all greater than grade 1 adverse events are listed regardless of attribution. ALT, alanine amino transferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase.

*

All patients had grade 4 lymphocyte count decreased, which was expected after the chemotherapy conditioning regimen that the patients received. Lymphocyte count decreased was not listed repetitively for each patient.

Creatine phosphokinase elevation in this patient was almost certainly caused by exercise.

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