Tier 3 treatment options
| Treatment . | Reference . | Dose . | Response rate (%) . | Selected toxicities . |
|---|---|---|---|---|
| ATRA | 86 | 10 mg orally 3 times per day | 29 | Retinoic acid syndrome, flu-like symptoms, musculoskeletal pain, nausea/vomiting, peripheral neuropathy |
| Autologous HSCT | 87 | Cyclophosphamide 50 mg/kg IV once per day × 4 days (conditioning) | 43 | Neutropenic fever, infection |
| Colchicine | 88 | 1.2 g orally once per day | 21 | Agranulocytosis, neuritis, diarrhea, nausea/vomiting |
| Interferon α | 89-92 | Various | 0-36 | Neutropenia, fever, influenza-like symptoms, hepatotoxicity |
| Plasma exchange | 93-95 | One plasma volume exchange once per day × 1 to 8 days | 29-80 | Hypocalcemia, anaphylactoid reactions |
| Protein A immunoadsorption | 96 | Average of 6 treatments (0.25 to 2.0 L plasma per treatment) over 2 to 3 weeks | 21 | Hypersensitivity reactions, pain, nausea/vomiting |
| Cardiopulmonary complications | ||||
| Vitamin C | 97-100 | 2 g orally once per day | 0-82 | Dsypepsia, nausea/vomiting |
| Treatment . | Reference . | Dose . | Response rate (%) . | Selected toxicities . |
|---|---|---|---|---|
| ATRA | 86 | 10 mg orally 3 times per day | 29 | Retinoic acid syndrome, flu-like symptoms, musculoskeletal pain, nausea/vomiting, peripheral neuropathy |
| Autologous HSCT | 87 | Cyclophosphamide 50 mg/kg IV once per day × 4 days (conditioning) | 43 | Neutropenic fever, infection |
| Colchicine | 88 | 1.2 g orally once per day | 21 | Agranulocytosis, neuritis, diarrhea, nausea/vomiting |
| Interferon α | 89-92 | Various | 0-36 | Neutropenia, fever, influenza-like symptoms, hepatotoxicity |
| Plasma exchange | 93-95 | One plasma volume exchange once per day × 1 to 8 days | 29-80 | Hypocalcemia, anaphylactoid reactions |
| Protein A immunoadsorption | 96 | Average of 6 treatments (0.25 to 2.0 L plasma per treatment) over 2 to 3 weeks | 21 | Hypersensitivity reactions, pain, nausea/vomiting |
| Cardiopulmonary complications | ||||
| Vitamin C | 97-100 | 2 g orally once per day | 0-82 | Dsypepsia, nausea/vomiting |
ATRA, all-trans retinoic acid; HSCT, hematopoietic stem cell transplant