Adverse events for patients treated at the MTD (dose level 4 of phase 1 and phase 2)
| n = 67 . | |||||
|---|---|---|---|---|---|
| Events . | Grade 2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5, n (%) . | Total, n (%) . |
| Hematologic | |||||
| Neutropenia | 8 (12) | 13 (19) | 2 (3) | — | 23 (34) |
| Thrombocytopenia | 10 (15) | 10 (15) | 5 (7) | — | 25 (37) |
| Anemia | 4 (6) | 3 (4) | — | — | 7 (10) |
| Nonhematologic | |||||
| Thromboembolism | — | 3 (4) | — | — | 3 (4) |
| Constitutional | 21 (31) | 2 (3) | — | — | 23 (34) |
| Fatigue | 9 (13) | 1 (1) | — | — | 10 (15) |
| Muscle cramps | 12 (18) | 1 (1) | — | — | 13 (19) |
| Neurologic | 4 (6) | 1 (1) | — | — | 5 (8) |
| Sensory neuropathy | 4 (6) | — | — | — | 4 (6) |
| Dysesthesia | — | 1 (1) | — | — | 1 (1) |
| Infections | 25 (37) | 12 (18) | — | 2 (3) | 39 (58) |
| Upper respiratory | 12 (18) | 4 (7) | — | — | 16 (24) |
| Pneumonia | 2 (3) | 6 (9) | — | 2 (3) | 10 (15) |
| Gastrointestinal | 5 (7) | 1 (1) | 6 (9) | ||
| Herpes zoster | 2 (3) | — | — | 2 (3) | |
| Other | 4 (7) | 1 (1) | — | — | 5 (7) |
| Cardiac disorders | — | 4 (7) | 1 (1) | — | 5 (7) |
| Congestive heart failure | — | 2 (3) | 1 (1) | — | 3 (4) |
| Arythmia | — | 1 (1) | — | — | 1 (1) |
| Angina pectoris | — | 1 (1) | — | — | 1 (1) |
| n = 67 . | |||||
|---|---|---|---|---|---|
| Events . | Grade 2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5, n (%) . | Total, n (%) . |
| Hematologic | |||||
| Neutropenia | 8 (12) | 13 (19) | 2 (3) | — | 23 (34) |
| Thrombocytopenia | 10 (15) | 10 (15) | 5 (7) | — | 25 (37) |
| Anemia | 4 (6) | 3 (4) | — | — | 7 (10) |
| Nonhematologic | |||||
| Thromboembolism | — | 3 (4) | — | — | 3 (4) |
| Constitutional | 21 (31) | 2 (3) | — | — | 23 (34) |
| Fatigue | 9 (13) | 1 (1) | — | — | 10 (15) |
| Muscle cramps | 12 (18) | 1 (1) | — | — | 13 (19) |
| Neurologic | 4 (6) | 1 (1) | — | — | 5 (8) |
| Sensory neuropathy | 4 (6) | — | — | — | 4 (6) |
| Dysesthesia | — | 1 (1) | — | — | 1 (1) |
| Infections | 25 (37) | 12 (18) | — | 2 (3) | 39 (58) |
| Upper respiratory | 12 (18) | 4 (7) | — | — | 16 (24) |
| Pneumonia | 2 (3) | 6 (9) | — | 2 (3) | 10 (15) |
| Gastrointestinal | 5 (7) | 1 (1) | 6 (9) | ||
| Herpes zoster | 2 (3) | — | — | 2 (3) | |
| Other | 4 (7) | 1 (1) | — | — | 5 (7) |
| Cardiac disorders | — | 4 (7) | 1 (1) | — | 5 (7) |
| Congestive heart failure | — | 2 (3) | 1 (1) | — | 3 (4) |
| Arythmia | — | 1 (1) | — | — | 1 (1) |
| Angina pectoris | — | 1 (1) | — | — | 1 (1) |