Table 1.

Some examples of monoclonal gammopathies of (possible) clinical significance but low malignant potential

TermOrganClinical settings, comment
MGRS Renal Renal lesions currently incorporated under monoclonal gammopathy of renal significance, including proliferative glomerulonephritis133  
MGBS Bone Acute osteoporosis and osteoporotic fractures 
MGDS Skin Cryoglobulin vasculitis, Schnitzler syndrome, necrobiotic xanthogranuloma, scleromyxedema, POEMS, pyoderma gangrenosum 
MGNS Neuropathies Spectrum of neuropathies with MGUS 
TermOrganClinical settings, comment
MGRS Renal Renal lesions currently incorporated under monoclonal gammopathy of renal significance, including proliferative glomerulonephritis133  
MGBS Bone Acute osteoporosis and osteoporotic fractures 
MGDS Skin Cryoglobulin vasculitis, Schnitzler syndrome, necrobiotic xanthogranuloma, scleromyxedema, POEMS, pyoderma gangrenosum 
MGNS Neuropathies Spectrum of neuropathies with MGUS 

MGBS, monoclonal gammopathy of bone significance; MGDS, monoclonal gammopathy of dermal significance; MGNS, monoclonal gammopathy of neuropathic significance; MGRS, monoclonal gammopathy of renal significance; POEMS, polyneuropathy, organomegaly, endocrinopathy, M spike, and Skin changes syndrome.

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