Maximal responses (Emax) from ADP concentration vs Ca2+ peak response curves (as calculated in GraphPad Prism) obtained in the presence of different P2Y12R antagonists
| Drug . | Emax (AU) . | P relative to control . | P relative to ticagrelor . | n . |
|---|---|---|---|---|
| Vehicle control | 0.92 [0.88-0.96] | NA | *** | 16 |
| Ticagrelor | 0.41 [0.38-0.45] | *** | NA | 22 |
| AR-C 66096 | 0.61 [0.56-0.66] | *** | *** | 12 |
| R-138727 | 0.61 [0.57-0.66] | *** | *** | 12 |
| Drug . | Emax (AU) . | P relative to control . | P relative to ticagrelor . | n . |
|---|---|---|---|---|
| Vehicle control | 0.92 [0.88-0.96] | NA | *** | 16 |
| Ticagrelor | 0.41 [0.38-0.45] | *** | NA | 22 |
| AR-C 66096 | 0.61 [0.56-0.66] | *** | *** | 12 |
| R-138727 | 0.61 [0.57-0.66] | *** | *** | 12 |
Responses were recorded from washed platelets after incubation with vehicle (0.1% DMSO) or test compound (all at 10 µM; 30 minutes). The 95% confidence for Emax values is shown in square brackets. ***P < .001.
NA, not applicable.