| Binder name . | Gene . | VEBIOS-Citrate . | VEBIOS-EDTA . | FARIVE-Citrate . | |||
|---|---|---|---|---|---|---|---|
| Controls . | Cases . | Controls . | Cases . | Controls . | Cases . | ||
| (N = 85) . | (N = 88) . | (N = 86) . | (N = 87) . | (N = 589) . | (N = 580) . | ||
| HPA050724 | HIVEP1 | 6.734 (0.012) | 6.820 (0.015) | 7.066 (0.015) | 7.172 (0.018) | 6.370 (0.006) | 6.384 (0.006) |
| β = +0.089 (0.019); P = 9.5 × 10−6 | β = +0.107 (0.023); P = 5.9 × 10−6 | β = +0.012 (0.009); P = .160 | |||||
| HPA059686 | GPX3 | 5.872 (0.016) | 5.788 (0.012) | 5.791 (0.021) | 5.713 (0.016) | 6.699 (0.006) | 6.679 (0.007) |
| β = −0.086 (0.019); P = 1.4 × 10−5 | β = −0.080 (0.025); P = 1.9 × 10−3 | β = −0.018 (0.009); P = .036 | |||||
| HPA002082 | VWF | 6.678 (0.025) | 6.845 (0.033) | 6.586 (0.030) | 6.841 (0.043) | 7.396 (0.015) | 7.529 (0.016) |
| β = +0.170 (0.040); P = 2.0 × 10−5 | β = −0.260 (0.048); P = 2.2 × 10−7 | β = +0.130 (0.021); P = 5.2 × 10−10 | |||||
| HPA011972 | PDGFB | 8.285 (0.012) | 8.363 (0.016) | 8.418 (0.013) | 8.480 (0.015) | 8.280 (0.005) | 8.317 (0.006) |
| β = +0.082 (0.019); P = 3.0 × 10−5 | β = +0.063 (0.019); P = 1.1 × 10−3 | β = +0.037 (0.007); P = 1.7 × 10−7 | |||||
| Binder name . | Gene . | VEBIOS-Citrate . | VEBIOS-EDTA . | FARIVE-Citrate . | |||
|---|---|---|---|---|---|---|---|
| Controls . | Cases . | Controls . | Cases . | Controls . | Cases . | ||
| (N = 85) . | (N = 88) . | (N = 86) . | (N = 87) . | (N = 589) . | (N = 580) . | ||
| HPA050724 | HIVEP1 | 6.734 (0.012) | 6.820 (0.015) | 7.066 (0.015) | 7.172 (0.018) | 6.370 (0.006) | 6.384 (0.006) |
| β = +0.089 (0.019); P = 9.5 × 10−6 | β = +0.107 (0.023); P = 5.9 × 10−6 | β = +0.012 (0.009); P = .160 | |||||
| HPA059686 | GPX3 | 5.872 (0.016) | 5.788 (0.012) | 5.791 (0.021) | 5.713 (0.016) | 6.699 (0.006) | 6.679 (0.007) |
| β = −0.086 (0.019); P = 1.4 × 10−5 | β = −0.080 (0.025); P = 1.9 × 10−3 | β = −0.018 (0.009); P = .036 | |||||
| HPA002082 | VWF | 6.678 (0.025) | 6.845 (0.033) | 6.586 (0.030) | 6.841 (0.043) | 7.396 (0.015) | 7.529 (0.016) |
| β = +0.170 (0.040); P = 2.0 × 10−5 | β = −0.260 (0.048); P = 2.2 × 10−7 | β = +0.130 (0.021); P = 5.2 × 10−10 | |||||
| HPA011972 | PDGFB | 8.285 (0.012) | 8.363 (0.016) | 8.418 (0.013) | 8.480 (0.015) | 8.280 (0.005) | 8.317 (0.006) |
| β = +0.082 (0.019); P = 3.0 × 10−5 | β = +0.063 (0.019); P = 1.1 × 10−3 | β = +0.037 (0.007); P = 1.7 × 10−7 | |||||
Shown values correspond to log MFI relative to levels of the protein targeted by the HPA antibodies separately in controls and cases with the standard error. The β coefficient (standard error) corresponds to the log level’s increase in cases compared with controls, adjusted for age, sex and additionally center in FARIVE.
The statistical thresholds used for declaring statistical association were P = 6.6 × 10−5 (∼0.05/755) in VEBIOS and P = .0125 (=.05/4) in FARIVE.