Differential expression of tetraspanins and BCR signaling-related genes between CD37− and CD37+ patients with GCB- or ABC-DLBCL
| CD37− vs CD37+ in GCB/ABC DLBCL . | |||
|---|---|---|---|
| Genes . | Downregulation in CD37− . | Genes . | Upregulation in CD37− . |
| CD37 | ↓ in both GCB (P = .036) and ABC (P < .0001) | CD63 | ↑ in ABC (P < .0001) |
| CD20 | ↓ in both GCB (P = .0008) and ABC (P = .0009) | MS4A4A (CD20L1) | ↑ in GCB (P = .0073) and ABC (P = .059) |
| CD79A | ↓ in both GCB (P = .002) and ABC (P = .009) | MS4A6A (CD20L3) | Trend of ↑ in ABC (P = .057) |
| CD79B | ↓ in ABC (P = .032) | AKT1 | ↑ in GCB (P = .019) |
| CD22 | ↓ in both GCB (P = .016) and ABC (P = .011) | ||
| CD23 | ↓ in GCB (P = .016) | ||
| STAP1 | ↓ in GCB (P = .0012) | ||
| SWAP70 | ↓ in GCB (P = .0036) | ||
| SYK | ↓ in ABC (P = .045) | ||
| CARD11 | ↓ in ABC (P = .05) | ||
| BCL10 | Trend of ↓ in ABC (P = .07) | ||
| MALT1 | ↓ in GCB (P = .021) | ||
| CD40 | ↓ in GCB (P = .016) | ||
| BLNK | Trend of ↓ in ABC (P = .064) | ||
| MYC | Trend of ↓ in ABC (P = .08) | ||
| REL | ↓ in GCB (P = .0031) | ||
| PIK3C2B | ↓ in GCB (P = .046) and ABC (P = .07) | ||
| A20/TNFAIP3 | ↓ in GCB (P = .018) | A20/TNFAIP3 | ↑ in ABC (P = .036) |
| CD37− vs CD37+ in GCB/ABC DLBCL . | |||
|---|---|---|---|
| Genes . | Downregulation in CD37− . | Genes . | Upregulation in CD37− . |
| CD37 | ↓ in both GCB (P = .036) and ABC (P < .0001) | CD63 | ↑ in ABC (P < .0001) |
| CD20 | ↓ in both GCB (P = .0008) and ABC (P = .0009) | MS4A4A (CD20L1) | ↑ in GCB (P = .0073) and ABC (P = .059) |
| CD79A | ↓ in both GCB (P = .002) and ABC (P = .009) | MS4A6A (CD20L3) | Trend of ↑ in ABC (P = .057) |
| CD79B | ↓ in ABC (P = .032) | AKT1 | ↑ in GCB (P = .019) |
| CD22 | ↓ in both GCB (P = .016) and ABC (P = .011) | ||
| CD23 | ↓ in GCB (P = .016) | ||
| STAP1 | ↓ in GCB (P = .0012) | ||
| SWAP70 | ↓ in GCB (P = .0036) | ||
| SYK | ↓ in ABC (P = .045) | ||
| CARD11 | ↓ in ABC (P = .05) | ||
| BCL10 | Trend of ↓ in ABC (P = .07) | ||
| MALT1 | ↓ in GCB (P = .021) | ||
| CD40 | ↓ in GCB (P = .016) | ||
| BLNK | Trend of ↓ in ABC (P = .064) | ||
| MYC | Trend of ↓ in ABC (P = .08) | ||
| REL | ↓ in GCB (P = .0031) | ||
| PIK3C2B | ↓ in GCB (P = .046) and ABC (P = .07) | ||
| A20/TNFAIP3 | ↓ in GCB (P = .018) | A20/TNFAIP3 | ↑ in ABC (P = .036) |
The P values were obtained by the unpaired Student t test (2-tailed).