Table 4. GEP analysis between CD37 and... | American Society of Hematology

Table 4.

GEP analysis between CD37⁺ and CD37⁻ DLBCL groups

Function categories	Upregulated	Downregulated
CD37⁻vs CD37⁺DLBCL (FDR <0.05)
Immune responses, inflammation, host defense	FCGR1B ↑ LILRB2 ↑ SERPING1 ↑ IRF1 ↑ TLR2 ↑ SAMHD1 ↑ IFITM1 ↑ IFITM3 ↑ PYCARD ↑ HEBP1 ↑
Signaling	FNIP2 ↑ RCAN1 ↑ SERPINA1 ↑	CD37 ↓ MS4A1/CD20 ↓ VSNL1 ↓ LPAR6 ↓
Differentiation	FNDC3B ↑	AICDA ↓ BCL11A ↓ FOXP1 ↓ XBP1 ↓ PAX5 ↓
Gene expression, translation, cell cycle	EIF1 ↑	CDK5R1 ↓ METTL2A/B ↓ ZNF581 ↓ ZNF765 ↓
Apoptosis, DNA damage response	DRAM1 ↑	C9orf102 ↓
Metabolism, protein repair and degradation, oxidative stress, lipid movement, transport, intracellular membrane trafficking	GCH1 ↑ MT1G ↑ MT1P2 ↑ PAM ↑ MT1E ↑ C11orf67 ↑ MT1E/MT1H/MT1M ↑ UBR1 ↑ APOL6 ↑ RCN1 ↑ PCMT1 ↑ MSRB2 ↑ NUB1 ↑ RAB6A ↑ ARF4 ↑ RAB1B ↑ AQP9 ↑ CDIPT ↑ C12orf62 ↑ DPYD ↑	ZDHHC21 ↓ GOLGA8A/B ↓
Adhesion, regulation of actin, cytoskeleton, exocytosis, and extracellular matrix	RAB27A ↑ AOC3 ↑ GPR124 ↑ NINJ1 ↑ WDR1 ↑ CRISPLD2 ↑ RHOU ↑	DMD ↓
Unknown function, RNA gene	ANKRD22 ↑ MOP-1 ↑ CNIH4 ↑ PLEKHO2 ↑ FTHP1 ↑ C4orf32 ↑ FAM167B ↑ PWWP2B ↑	FAM129C ↓ NAPSB ↓ SNORA74A ↓ BRWD2 ↓ FAM108C1 ↓ LOC283887 ↓ RAB7L1 ↓ LOC133874 ↓
CD37⁻vs CD37⁺ABC-DLBCL (FDR <0.05)
Immune responses, inflammation, host defense	LILRB2 ↑ C1S ↑ AIF1 ↑ IFITM1 ↑ IFITM3 ↑ SERPING1 ↑ HLA-C ↑ LST1 ↑ B2M ↑ ISG15 ↑
Signaling	SRC ↑ STAT4 ↑ CD63 ↑ SEMA4D ↑ SECTM1 ↑ VDR ↑ RCAN1 ↑ ACVRL1 ↑ PREX1 ↑ PROCR ↑ TNIP2 ↑ RALB ↑	CD37 ↓
Differentiation		AICDA ↓ BCL11A ↓ FOXP1 ↓ IKZF1 ↓ PAX5 ↓
Gene expression, translation	TCF7L2 ↑ EIF4E3 ↑ EIF1 ↑ C14orf4 ↑ KLF3 ↑	TBL1XR1 ↓ HELLS ↓ RPS2 ↓ EBF1 ↓ ZNF587 ↓
Apoptosis, autophagy, DNA repair	DRAM1 ↑ C19orf40 ↑	C9orf102 ↓
Metabolism, ion channel, transport, trafficking, protein degradation	FAM26F ↑ GCH1 ↑ MT1P2 ↑ MT1E ↑ STOM ↑ MT1E/MT1H/MT1M ↑ ACSL1 ↑ AAK1 ↑ VAMP5 ↑ RAB13 ↑ RCN1 ↑ RNF217 ↑ RAB6A ↑ MGST2 ↑ BLVRA ↑ C14orf133 ↑ PDXK ↑ GMPPA ↑ HTATIP2 ↑ HEBP1 ↑ CHP1 ↑	C7orf68 ↓ GOLGA8B ↓ RIMKLB ↓ DPY19L2 ↓ UBE3C ↓ DNAJB7 ↓
Adhesion, regulation of actin, cytoskeleton, exocytosis, and extracellular matrix	RAB27A ↑ PECAM1 ↑ RHOU ↑ MYOF ↑ DYSF ↑ CCDC80 ↑ AOC3 ↑ CTNNA1 ↑ GPR124 ↑	RALGPS2 ↓
Unknown function, RNA gene	ANKRD22 ↑ GLIPR2 ↑ NKG7 ↑ CNIH4 ↑ SAMD3 ↑ TMEM176A ↑ SLFN12 ↑ PLEKHO2 ↑ C21orf33/PWP2 ↑	FAM129C ↓ C13orf18 ↓ NAPSB ↓ SNORA68 ↓ SNORA74A ↓ BRWD2 ↓ FAM108C1 ↓ SNORD104 ↓ FLJ43663 ↓ SNHG12 ↓ PMS2L1 ↓ LOC284513 ↓
PI3K^high/CD37⁻vs PI3K^high/CD37⁺ABC-DLBCL (FDR <0.01)
Immune responses, inflammation, host defense	FCGR1B ↑ GBP1 ↑ FPR2 ↑ TRBC1 ↑ IFITM1 ↑ FCGR3B ↑ FCGR1A/C ↑ C3AR1 ↑ CD14 ↑
Signaling	SECTM1 ↑ TNFSF10 ↑ SEMA4D ↑ APLP2 ↑
Differentiation, transcription factors	BCL11B ↑ KLF3 ↑
Cell cycle	CCND1 ↑ PTP4A2 ↑
Apoptosis	DRAM1 ↑ EPB41L3 ↑
Ion channel, transport, trafficking, protein degradation, metabolism	MT1H ↑ FAM26F ↑ MT1G ↑ MT2A ↑ MT1X ↑ CPD ↑ MT1E/MT1H/MT1M ↑ SLC8A1 ↑ MT1E ↑ AAK1 ↑ LYST ↑ APOL6 ↑ RAB1A ↑
Adhesion	PECAM1 ↑
RNA regulation, unknown function	ANKRD22 ↑ ZC3H12C ↑ GLIPR2 ↑	SNORD104 ↓
CD37⁻ABC vs CD37⁻GCB (FDR <0.01, fold change >2)
Immune responses, inflammation	TNFRSF13B ↑ S100A8 ↑ GZMB ↑ CLECL1 ↑ LILRB2 ↑ FCRL5 ↑ CCL8 ↑	IGHG1 ↓
Signaling	IGHM ↑	MME ↓ STAP1 ↓
Transcription regulation, DNA replication, microRNA	BATF ↑ IRF4 ↑ MIR155HG ↑	MYBL1 ↓ ELL3/SERINC4 ↓ STAG3 ↓ SSBP2 ↓ BCL6 ↓
Metabolism, ion channel	FUT8 ↑ FAM26F ↑ DHRS9 ↑
Adhesion, cytoskeleton, extracellular matrix	TUBB4 ↑ CD44 ↑	CILP ↓ KANK1 ↓ PCDHGB7 ↓ MARCKSL1 ↓
Unknown function	ANKRD22 ↑ C1orf186 ↑C13orf18 ↑ MPEG1 ↑	FLJ42418 ↓C17orf99 ↓ TMEM108 ↓ TEX9 ↓ CRNDE ↓ CCDC85A ↓ BTNL9 ↓ KIAA0746 ↓
CD37⁺ABC vs CD37⁺GCB (FDR <0.01, fold change >2.18)
Immune responses	TNFRSF13B ↑ CLECL1 ↑ FCRL5 ↑ GZMB ↑	IGHG1 ↓ HLA-DOB ↓ LRMP ↓ CXCL14 ↓
Signaling	IGHM ↑ BLNK ↑	MME ↓ STAP1 ↓ PTPRS ↓ SPRED2 ↓ PDE4D ↓ RRAS2 ↓ FNDC1 ↓
Differentiation	AICDA ↑	LMO2 ↓
Transcription regulation, DNA replication, microRNA	FOXP1 ↑ PARP15 ↑ BATF ↑ TCF4 ↑ IRF4 ↑ MIR155HG ↑	MYBL1 ↓ STAG3 ↓ HOPX ↓TOX ↓ SSBP2 ↓ REL ↓
Cell cycle		NEK6 ↓
Metabolism, transport	XK ↑ P2RX5 ↑ FUT8 ↑ SLC2A13 ↑	SLC12A8 ↓ PLEKHF2 ↓ GALNT14 ↓ SULF1 ↓ LHPP ↓
Adhesion, cytoskeleton, extracellular matrix, migration	TUBB4 ↑	CILP ↓ POSTN ↓ MARCKSL1 ↓ DPT ↓ PCDHGB7 ↓ RAPH1 ↓ CPNE3 ↓ COL5A1 ↓ KANK1 ↓ PTK2 ↓
Unknown function	C13orf18 ↑ FAM129C ↑ C1orf186 ↑ TBC1D27 ↑ MPEG1 ↑	C17orf99 ↓ FLJ42418 ↓ CCDC144B ↓ TMEM108 ↓ BTNL9 ↓ PRO1483 ↓ CCDC85A ↓ KIAA0746 ↓

Function categories	Upregulated	Downregulated
CD37⁻vs CD37⁺DLBCL (FDR <0.05)
Immune responses, inflammation, host defense	FCGR1B ↑ LILRB2 ↑ SERPING1 ↑ IRF1 ↑ TLR2 ↑ SAMHD1 ↑ IFITM1 ↑ IFITM3 ↑ PYCARD ↑ HEBP1 ↑
Signaling	FNIP2 ↑ RCAN1 ↑ SERPINA1 ↑	CD37 ↓ MS4A1/CD20 ↓ VSNL1 ↓ LPAR6 ↓
Differentiation	FNDC3B ↑	AICDA ↓ BCL11A ↓ FOXP1 ↓ XBP1 ↓ PAX5 ↓
Gene expression, translation, cell cycle	EIF1 ↑	CDK5R1 ↓ METTL2A/B ↓ ZNF581 ↓ ZNF765 ↓
Apoptosis, DNA damage response	DRAM1 ↑	C9orf102 ↓
Metabolism, protein repair and degradation, oxidative stress, lipid movement, transport, intracellular membrane trafficking	GCH1 ↑ MT1G ↑ MT1P2 ↑ PAM ↑ MT1E ↑ C11orf67 ↑ MT1E/MT1H/MT1M ↑ UBR1 ↑ APOL6 ↑ RCN1 ↑ PCMT1 ↑ MSRB2 ↑ NUB1 ↑ RAB6A ↑ ARF4 ↑ RAB1B ↑ AQP9 ↑ CDIPT ↑ C12orf62 ↑ DPYD ↑	ZDHHC21 ↓ GOLGA8A/B ↓
Adhesion, regulation of actin, cytoskeleton, exocytosis, and extracellular matrix	RAB27A ↑ AOC3 ↑ GPR124 ↑ NINJ1 ↑ WDR1 ↑ CRISPLD2 ↑ RHOU ↑	DMD ↓
Unknown function, RNA gene	ANKRD22 ↑ MOP-1 ↑ CNIH4 ↑ PLEKHO2 ↑ FTHP1 ↑ C4orf32 ↑ FAM167B ↑ PWWP2B ↑	FAM129C ↓ NAPSB ↓ SNORA74A ↓ BRWD2 ↓ FAM108C1 ↓ LOC283887 ↓ RAB7L1 ↓ LOC133874 ↓
CD37⁻vs CD37⁺ABC-DLBCL (FDR <0.05)
Immune responses, inflammation, host defense	LILRB2 ↑ C1S ↑ AIF1 ↑ IFITM1 ↑ IFITM3 ↑ SERPING1 ↑ HLA-C ↑ LST1 ↑ B2M ↑ ISG15 ↑
Signaling	SRC ↑ STAT4 ↑ CD63 ↑ SEMA4D ↑ SECTM1 ↑ VDR ↑ RCAN1 ↑ ACVRL1 ↑ PREX1 ↑ PROCR ↑ TNIP2 ↑ RALB ↑	CD37 ↓
Differentiation		AICDA ↓ BCL11A ↓ FOXP1 ↓ IKZF1 ↓ PAX5 ↓
Gene expression, translation	TCF7L2 ↑ EIF4E3 ↑ EIF1 ↑ C14orf4 ↑ KLF3 ↑	TBL1XR1 ↓ HELLS ↓ RPS2 ↓ EBF1 ↓ ZNF587 ↓
Apoptosis, autophagy, DNA repair	DRAM1 ↑ C19orf40 ↑	C9orf102 ↓
Metabolism, ion channel, transport, trafficking, protein degradation	FAM26F ↑ GCH1 ↑ MT1P2 ↑ MT1E ↑ STOM ↑ MT1E/MT1H/MT1M ↑ ACSL1 ↑ AAK1 ↑ VAMP5 ↑ RAB13 ↑ RCN1 ↑ RNF217 ↑ RAB6A ↑ MGST2 ↑ BLVRA ↑ C14orf133 ↑ PDXK ↑ GMPPA ↑ HTATIP2 ↑ HEBP1 ↑ CHP1 ↑	C7orf68 ↓ GOLGA8B ↓ RIMKLB ↓ DPY19L2 ↓ UBE3C ↓ DNAJB7 ↓
Adhesion, regulation of actin, cytoskeleton, exocytosis, and extracellular matrix	RAB27A ↑ PECAM1 ↑ RHOU ↑ MYOF ↑ DYSF ↑ CCDC80 ↑ AOC3 ↑ CTNNA1 ↑ GPR124 ↑	RALGPS2 ↓
Unknown function, RNA gene	ANKRD22 ↑ GLIPR2 ↑ NKG7 ↑ CNIH4 ↑ SAMD3 ↑ TMEM176A ↑ SLFN12 ↑ PLEKHO2 ↑ C21orf33/PWP2 ↑	FAM129C ↓ C13orf18 ↓ NAPSB ↓ SNORA68 ↓ SNORA74A ↓ BRWD2 ↓ FAM108C1 ↓ SNORD104 ↓ FLJ43663 ↓ SNHG12 ↓ PMS2L1 ↓ LOC284513 ↓
PI3K^high/CD37⁻vs PI3K^high/CD37⁺ABC-DLBCL (FDR <0.01)
Immune responses, inflammation, host defense	FCGR1B ↑ GBP1 ↑ FPR2 ↑ TRBC1 ↑ IFITM1 ↑ FCGR3B ↑ FCGR1A/C ↑ C3AR1 ↑ CD14 ↑
Signaling	SECTM1 ↑ TNFSF10 ↑ SEMA4D ↑ APLP2 ↑
Differentiation, transcription factors	BCL11B ↑ KLF3 ↑
Cell cycle	CCND1 ↑ PTP4A2 ↑
Apoptosis	DRAM1 ↑ EPB41L3 ↑
Ion channel, transport, trafficking, protein degradation, metabolism	MT1H ↑ FAM26F ↑ MT1G ↑ MT2A ↑ MT1X ↑ CPD ↑ MT1E/MT1H/MT1M ↑ SLC8A1 ↑ MT1E ↑ AAK1 ↑ LYST ↑ APOL6 ↑ RAB1A ↑
Adhesion	PECAM1 ↑
RNA regulation, unknown function	ANKRD22 ↑ ZC3H12C ↑ GLIPR2 ↑	SNORD104 ↓
CD37⁻ABC vs CD37⁻GCB (FDR <0.01, fold change >2)
Immune responses, inflammation	TNFRSF13B ↑ S100A8 ↑ GZMB ↑ CLECL1 ↑ LILRB2 ↑ FCRL5 ↑ CCL8 ↑	IGHG1 ↓
Signaling	IGHM ↑	MME ↓ STAP1 ↓
Transcription regulation, DNA replication, microRNA	BATF ↑ IRF4 ↑ MIR155HG ↑	MYBL1 ↓ ELL3/SERINC4 ↓ STAG3 ↓ SSBP2 ↓ BCL6 ↓
Metabolism, ion channel	FUT8 ↑ FAM26F ↑ DHRS9 ↑
Adhesion, cytoskeleton, extracellular matrix	TUBB4 ↑ CD44 ↑	CILP ↓ KANK1 ↓ PCDHGB7 ↓ MARCKSL1 ↓
Unknown function	ANKRD22 ↑ C1orf186 ↑C13orf18 ↑ MPEG1 ↑	FLJ42418 ↓C17orf99 ↓ TMEM108 ↓ TEX9 ↓ CRNDE ↓ CCDC85A ↓ BTNL9 ↓ KIAA0746 ↓
CD37⁺ABC vs CD37⁺GCB (FDR <0.01, fold change >2.18)
Immune responses	TNFRSF13B ↑ CLECL1 ↑ FCRL5 ↑ GZMB ↑	IGHG1 ↓ HLA-DOB ↓ LRMP ↓ CXCL14 ↓
Signaling	IGHM ↑ BLNK ↑	MME ↓ STAP1 ↓ PTPRS ↓ SPRED2 ↓ PDE4D ↓ RRAS2 ↓ FNDC1 ↓
Differentiation	AICDA ↑	LMO2 ↓
Transcription regulation, DNA replication, microRNA	FOXP1 ↑ PARP15 ↑ BATF ↑ TCF4 ↑ IRF4 ↑ MIR155HG ↑	MYBL1 ↓ STAG3 ↓ HOPX ↓TOX ↓ SSBP2 ↓ REL ↓
Cell cycle		NEK6 ↓
Metabolism, transport	XK ↑ P2RX5 ↑ FUT8 ↑ SLC2A13 ↑	SLC12A8 ↓ PLEKHF2 ↓ GALNT14 ↓ SULF1 ↓ LHPP ↓
Adhesion, cytoskeleton, extracellular matrix, migration	TUBB4 ↑	CILP ↓ POSTN ↓ MARCKSL1 ↓ DPT ↓ PCDHGB7 ↓ RAPH1 ↓ CPNE3 ↓ COL5A1 ↓ KANK1 ↓ PTK2 ↓
Unknown function	C13orf18 ↑ FAM129C ↑ C1orf186 ↑ TBC1D27 ↑ MPEG1 ↑	C17orf99 ↓ FLJ42418 ↓ CCDC144B ↓ TMEM108 ↓ BTNL9 ↓ PRO1483 ↓ CCDC85A ↓ KIAA0746 ↓

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