SNPs with significant prognostic impact for PFS and OS
| SNP (rs#) . | Gene . | Location . | Base change . | Genotype and distribution . | Association . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|
| rs1672753 | CRBN | 5′UTR | A>G | GG/GA/AA (4/44/137) | PFS | 0.59 | 0.40-0.86 | .006 |
| rs1672753 | CRBN | 5′UTR | A>G | GG/GA/AA (4/44/137) | OS | 0.55 | 0.33-0.92 | .023 |
| rs2440 | XRCC5 | 3′UTR | G>A | AA/AG/GG (32/79/76) | OS | 1.70 | 1.11-2.61 | .015 |
| rs4646903 | CYP1A1 | 3′UTR | A>G | GG/GA/AA (1/49/137) | OS | 1.59 | 1.04-2.43 | .033 |
| rs363717 | ABCA1 | 3′UTR | T>C | CC/CT/TT (7/49/131) | PFS | 1.44 | 1.03-2.02 | .033 |
| rs361525 | TNF-α | 5′UTR | G>A | AA/AG/GG (0/18/169) | PFS | 1.70 | 1.03-2.81 | .037 |
| rs1056836 | CYP1B1 | Exon | G>C | CC/CG/GG (42/77/68) | PFS | 0.72 | 0.52-0.99 | .043 |
| SNP (rs#) . | Gene . | Location . | Base change . | Genotype and distribution . | Association . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|
| rs1672753 | CRBN | 5′UTR | A>G | GG/GA/AA (4/44/137) | PFS | 0.59 | 0.40-0.86 | .006 |
| rs1672753 | CRBN | 5′UTR | A>G | GG/GA/AA (4/44/137) | OS | 0.55 | 0.33-0.92 | .023 |
| rs2440 | XRCC5 | 3′UTR | G>A | AA/AG/GG (32/79/76) | OS | 1.70 | 1.11-2.61 | .015 |
| rs4646903 | CYP1A1 | 3′UTR | A>G | GG/GA/AA (1/49/137) | OS | 1.59 | 1.04-2.43 | .033 |
| rs363717 | ABCA1 | 3′UTR | T>C | CC/CT/TT (7/49/131) | PFS | 1.44 | 1.03-2.02 | .033 |
| rs361525 | TNF-α | 5′UTR | G>A | AA/AG/GG (0/18/169) | PFS | 1.70 | 1.03-2.81 | .037 |
| rs1056836 | CYP1B1 | Exon | G>C | CC/CG/GG (42/77/68) | PFS | 0.72 | 0.52-0.99 | .043 |
HR represents hazard of patients with at least 1 minor allele vs patients with 2 major alleles.
CI, confidence interval.