SNPs having significant interactions with treatment allocation in PFS and OS
| SNP (rs#) . | Gene . | Location . | Base change . | Genotype and distribution . | Association . | 2 minor alleles and heterozygote . | 2 major alleles . | P-value interaction . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | HR . | 95% CI . | |||||||
| rs1053667 | FAM179B | 3′UTR | T>C | CC/CT/TT (0/21/162) | PFS | 2.27 | 0.78-6.67 | 0.47 | 0.33-0.66 | .003 |
| rs1799969 | ICAM1 | Exon | G>A | AA/AG/GG (0/33/154) | PFS | 1.75 | 0.83-3.70 | 0.51 | 0.36-0.73 | .007 |
| rs1799969 | ICAM1 | Exon | G>A | AA/AG/GG (0/33/154) | OS | 2.24 | 0.92-5.43 | 0.62 | 0.39-0.97 | .009 |
| rs1049216 | CASP3 | 3′UTR | A>G | GG/GA/AA (19/64/103) | PFS | 0.41 | 0.25-0.69 | 0.83 | 0.54-1.25 | .029 |
| rs6103 | SERPINB2 | Exon | C>G | GG/GC/CC (14/64/103) | OS | 1.24 | 0.68-2.24 | 0.52 | 0.30-0.93 | .041 |
| rs17655 | ERCC5 | Exon | G>C | CC/CG/GG (12/63/112) | OS | 0.46 | 0.25-0.87 | 1.09 | 0.65-1.83 | .043 |
| SNP (rs#) . | Gene . | Location . | Base change . | Genotype and distribution . | Association . | 2 minor alleles and heterozygote . | 2 major alleles . | P-value interaction . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | HR . | 95% CI . | |||||||
| rs1053667 | FAM179B | 3′UTR | T>C | CC/CT/TT (0/21/162) | PFS | 2.27 | 0.78-6.67 | 0.47 | 0.33-0.66 | .003 |
| rs1799969 | ICAM1 | Exon | G>A | AA/AG/GG (0/33/154) | PFS | 1.75 | 0.83-3.70 | 0.51 | 0.36-0.73 | .007 |
| rs1799969 | ICAM1 | Exon | G>A | AA/AG/GG (0/33/154) | OS | 2.24 | 0.92-5.43 | 0.62 | 0.39-0.97 | .009 |
| rs1049216 | CASP3 | 3′UTR | A>G | GG/GA/AA (19/64/103) | PFS | 0.41 | 0.25-0.69 | 0.83 | 0.54-1.25 | .029 |
| rs6103 | SERPINB2 | Exon | C>G | GG/GC/CC (14/64/103) | OS | 1.24 | 0.68-2.24 | 0.52 | 0.30-0.93 | .041 |
| rs17655 | ERCC5 | Exon | G>C | CC/CG/GG (12/63/112) | OS | 0.46 | 0.25-0.87 | 1.09 | 0.65-1.83 | .043 |
HR represents hazard of treatment vs observation for each genotype group.
Abbreviations are explained in Table 1.