Frequency of cytogenetic aberrations
| FISH cytogenetic aberrations . | Transplant group (n = 123) . | Drop-out group (n = 17)† . | ||
|---|---|---|---|---|
| No.* . | % . | No.* . | % . | |
| IgH translocations | ||||
| t(11;14) | 72/123 | 59 | 9/17 | 53 |
| t(4;14) | 5/123 | 4 | 0/16 | 0 |
| t(14;16) | 1/122 | 1 | 1/16 | 6 |
| IgH translocation with unknown partner | 20/12 | 1 17 | 2/16 | 13 |
| Gain | ||||
| 1q21 | 25/116 | 22 | 2/16 | 13 |
| 5p15/5q35 | 9/110 | 8 | 0/15 | 0 |
| 9q34 | 25/112 | 22 | 0/15 | 0 |
| 15q22 | 16/110 | 15 | 0/15 | 0 |
| 19q13 | 16/114 | 14 | 0/16 | 0 |
| Deletion | ||||
| 13q14 | 36/123 | 29 | 5/16 | 31 |
| 17p13 | 3/123 | 2 | 0/16 | 0 |
| Hyperdiploidy‡ | 16/111 | 14 | 0/15 | 0 |
| High-risk aberrations§ | 9/122 | 7 | 1/16 | 6 |
| Normal iFISH, no aberration detected | 7/123 | 6 | 3/17 | 18 |
| FISH cytogenetic aberrations . | Transplant group (n = 123) . | Drop-out group (n = 17)† . | ||
|---|---|---|---|---|
| No.* . | % . | No.* . | % . | |
| IgH translocations | ||||
| t(11;14) | 72/123 | 59 | 9/17 | 53 |
| t(4;14) | 5/123 | 4 | 0/16 | 0 |
| t(14;16) | 1/122 | 1 | 1/16 | 6 |
| IgH translocation with unknown partner | 20/12 | 1 17 | 2/16 | 13 |
| Gain | ||||
| 1q21 | 25/116 | 22 | 2/16 | 13 |
| 5p15/5q35 | 9/110 | 8 | 0/15 | 0 |
| 9q34 | 25/112 | 22 | 0/15 | 0 |
| 15q22 | 16/110 | 15 | 0/15 | 0 |
| 19q13 | 16/114 | 14 | 0/16 | 0 |
| Deletion | ||||
| 13q14 | 36/123 | 29 | 5/16 | 31 |
| 17p13 | 3/123 | 2 | 0/16 | 0 |
| Hyperdiploidy‡ | 16/111 | 14 | 0/15 | 0 |
| High-risk aberrations§ | 9/122 | 7 | 1/16 | 6 |
| Normal iFISH, no aberration detected | 7/123 | 6 | 3/17 | 18 |
IgH, immunoglobulin H.
Frequencies (no./N) of the respective cytogenetic aberrations are shown.
Refers to the patients initially deemed eligible for HDM who could not proceed to HDM as a result of TRM, AL progression, or treatment toxicity during the induction or the mobilization phase or because they were unable to mobilize stem cells.
Hyperdiploidy is defined as trisomies of least 2 of the 3 loci (5p15/5q35, 9q34, and 15q22), according to Wuilleme et al.26
High-risk aberrations are defined by the detection of t(4;14), t(14;16), or del(17p13).18