RBC parameters in 15-month-old double-heterozygote mice reveal a significant increase in RBC number and hemoglobin with a decrease in reticulocyte count and RDW in comparison with th3/+ mice
| . | Hemoglobin (g/dL) . | RBCs (106 cells/μL) . | Reticulocytes (109 cells/L) . | RDW (%) . | MCV (fL) . | MCH (pg) . |
|---|---|---|---|---|---|---|
| th3/+ | 7 ± 0.3 | 8 ± 0.2 | 1544 ± 64 | 36 ± 0.2 | 38 ± 1.4 | 8 ± 0.1 |
| Double-het | 10 ± 0.3*** | 12 ± 0.4*** | 965 ± 113*** | 27 ± 1.9** | 35 ± 0.4 | 8 ± 0.1 |
| . | Hemoglobin (g/dL) . | RBCs (106 cells/μL) . | Reticulocytes (109 cells/L) . | RDW (%) . | MCV (fL) . | MCH (pg) . |
|---|---|---|---|---|---|---|
| th3/+ | 7 ± 0.3 | 8 ± 0.2 | 1544 ± 64 | 36 ± 0.2 | 38 ± 1.4 | 8 ± 0.1 |
| Double-het | 10 ± 0.3*** | 12 ± 0.4*** | 965 ± 113*** | 27 ± 1.9** | 35 ± 0.4 | 8 ± 0.1 |
Data represent means ± standard errors of the mean; n = 3–4 mice per group.
Double-het, double-heterozygote mice.
P < .01; ***P < .001 vs th3/+ mice.