LFA-1 specific antibody binding sites and effects on LFA-1 and α4β1 activity
| . | Chain . | Binding site . | Lfa-1 activity . | α4β1 activity . |
|---|---|---|---|---|
| CBR LFA-1/2 | β2 | I-EGF-3 | Activating | Inhibiting |
| MEM48 | β2 | I-EGF-3 | Activating | Inhibiting |
| MEM148 | β2 | Hybrid | Activating | Inhibiting |
| 7E4 | β2 | Hybrid | Inhibiting | Inhibiting |
| TS1/18 | β2 | β I-LIKE | Inhibiting | Inhibiting |
| MHM23 | β2 | β I-LIKE | Inhibiting | No effect |
| CBR LFA-1/7 | β2 | I-EGF-1 | No effect | No effect |
| MEM83 | αL | α I-domain | Activating | Inhibiting |
| TS1/22 | αL | α I-domain | Inhibiting | No effect |
| MHM24 | αL | α I-domain | Inhibiting | Inhibiting |
| TS2/4 | αL | β propeller | No effect | No effect |
| . | Chain . | Binding site . | Lfa-1 activity . | α4β1 activity . |
|---|---|---|---|---|
| CBR LFA-1/2 | β2 | I-EGF-3 | Activating | Inhibiting |
| MEM48 | β2 | I-EGF-3 | Activating | Inhibiting |
| MEM148 | β2 | Hybrid | Activating | Inhibiting |
| 7E4 | β2 | Hybrid | Inhibiting | Inhibiting |
| TS1/18 | β2 | β I-LIKE | Inhibiting | Inhibiting |
| MHM23 | β2 | β I-LIKE | Inhibiting | No effect |
| CBR LFA-1/7 | β2 | I-EGF-1 | No effect | No effect |
| MEM83 | αL | α I-domain | Activating | Inhibiting |
| TS1/22 | αL | α I-domain | Inhibiting | No effect |
| MHM24 | αL | α I-domain | Inhibiting | Inhibiting |
| TS2/4 | αL | β propeller | No effect | No effect |