Second-order rate constants of inhibition of thrombin, APC, fXa, and fXIa by α1AT variants
| Variant . | k2 (M−1·s−1) . | |||
|---|---|---|---|---|
| Thrombin . | APC . | fXa . | fXIa . | |
| PRS α1AT | (2.93 ± 0.18) × 105 | (1.08 ± 0.071) × 105 | (4.13 ± 0.24) × 104 | (4.00 ± 0.13) × 105 |
| KRS α1AT | (5.10 ± 0.28) × 101 | (6.48 ± 0.71) × 104 | (3.93 ± 0.31) × 103 | ND |
| PRK α1AT | (1.74 ± 0.17) × 102 | (9.57 ± 1.37) × 104 | (4.89 ± 0.16) × 103 | ND |
| KRK α1AT | No detectable inhibition | (1.51 ± 0.17) × 104 | (1.16 ± 0.10) × 102 | (4.71 ± 0.37) × 102 |
| Variant . | k2 (M−1·s−1) . | |||
|---|---|---|---|---|
| Thrombin . | APC . | fXa . | fXIa . | |
| PRS α1AT | (2.93 ± 0.18) × 105 | (1.08 ± 0.071) × 105 | (4.13 ± 0.24) × 104 | (4.00 ± 0.13) × 105 |
| KRS α1AT | (5.10 ± 0.28) × 101 | (6.48 ± 0.71) × 104 | (3.93 ± 0.31) × 103 | ND |
| PRK α1AT | (1.74 ± 0.17) × 102 | (9.57 ± 1.37) × 104 | (4.89 ± 0.16) × 103 | ND |
| KRK α1AT | No detectable inhibition | (1.51 ± 0.17) × 104 | (1.16 ± 0.10) × 102 | (4.71 ± 0.37) × 102 |
Values are rate constants plus or minus standard error.
ND, not determined.