Univariate and multivariate Cox proportional hazard regression analysis for PFS and OS
| . | Univariate analysis . | Multivariate analysis . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Predictors for PFS . | . | Model 1 . | Model 2 . | ||||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥65 | 1.4 | 0.9-2.1 | .09 | ||||||
| No. of involved organ >2 | 2 | 1.2-3.2 | .005 | 1.8 | 1.1-3 | .02 | 1.6 | 0.99-2.6 | .02 |
| ≥2.5% monotypic PCs | 1.7 | 1.2-2.6 | .007 | 1.8 | 1.2-2.7 | .006 | Not included | ||
| pPC/BMPC ratio ≤5% | 1.6 | 1.1-2.5 | .02 | Not included | 1.6 | 1.1-2.5 | .01 | ||
| Mayo stage 2004 | |||||||||
| 1 | Reference | 1.1-4.1 | .01 | Reference | 0.9-3.2 | .13 | Reference | 0.8-3.1 | .18 |
| 2 | 2.1 | 2.1-7.1 | <.001 | 1.6 | 1.4-5.1 | .002 | 1.5 | 1.3-5 | .003 |
| 3 | 3.8 | 2.6 | 2.5 | ||||||
| dFLC ≥18 mg/dL | 1.4 | 0.9-2.1 | .15 | ||||||
| ASCT at first line | 0.4 | 0.3-0.6 | <.0001 | 0.6 | 0.3-0.9 | .01 | 0.5 | 0.3-0.9 | .01 |
| . | Univariate analysis . | Multivariate analysis . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Predictors for PFS . | . | Model 1 . | Model 2 . | ||||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥65 | 1.4 | 0.9-2.1 | .09 | ||||||
| No. of involved organ >2 | 2 | 1.2-3.2 | .005 | 1.8 | 1.1-3 | .02 | 1.6 | 0.99-2.6 | .02 |
| ≥2.5% monotypic PCs | 1.7 | 1.2-2.6 | .007 | 1.8 | 1.2-2.7 | .006 | Not included | ||
| pPC/BMPC ratio ≤5% | 1.6 | 1.1-2.5 | .02 | Not included | 1.6 | 1.1-2.5 | .01 | ||
| Mayo stage 2004 | |||||||||
| 1 | Reference | 1.1-4.1 | .01 | Reference | 0.9-3.2 | .13 | Reference | 0.8-3.1 | .18 |
| 2 | 2.1 | 2.1-7.1 | <.001 | 1.6 | 1.4-5.1 | .002 | 1.5 | 1.3-5 | .003 |
| 3 | 3.8 | 2.6 | 2.5 | ||||||
| dFLC ≥18 mg/dL | 1.4 | 0.9-2.1 | .15 | ||||||
| ASCT at first line | 0.4 | 0.3-0.6 | <.0001 | 0.6 | 0.3-0.9 | .01 | 0.5 | 0.3-0.9 | .01 |
| Predictors for OS . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | . | . | . |
|---|---|---|---|---|---|---|---|---|---|
| Age ≥65 | 1.8 | 1.1-3.1 | .01 | 1.4 | 0.8-2.4 | .19 | |||
| No. of involved organ > 2 | 2.1 | 1.2-3.5 | .008 | 1.7 | 1-3 | .05 | |||
| ≥2.5% monotypic PCs | 1.9 | 1.2-3.1 | .01 | 1.9 | 1.1-3.1 | .01 | |||
| pPC/BMPC ratio ≤5% | 1.4 | 0.8-2.3 | .19 | ||||||
| Mayo stage 2004 | |||||||||
| 1 | Reference | 1.6-4.8 | .002 | Reference | 1-12.6 | .05 | |||
| 2 | 2.8 | 4.8-55 | <.0001 | 2.9 | 2.3-28 | .0001 | |||
| 3 | 13.3 | 6.6 | |||||||
| dFLC ≥18 mg/dL | 1.5 | 0.9-2.6 | .11 | ||||||
| ASCT at first line | 0.1 | 0.05-0.3 | <.0001 | 0.3 | 0.1-0.6 | .0005 |
| Predictors for OS . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | . | . | . |
|---|---|---|---|---|---|---|---|---|---|
| Age ≥65 | 1.8 | 1.1-3.1 | .01 | 1.4 | 0.8-2.4 | .19 | |||
| No. of involved organ > 2 | 2.1 | 1.2-3.5 | .008 | 1.7 | 1-3 | .05 | |||
| ≥2.5% monotypic PCs | 1.9 | 1.2-3.1 | .01 | 1.9 | 1.1-3.1 | .01 | |||
| pPC/BMPC ratio ≤5% | 1.4 | 0.8-2.3 | .19 | ||||||
| Mayo stage 2004 | |||||||||
| 1 | Reference | 1.6-4.8 | .002 | Reference | 1-12.6 | .05 | |||
| 2 | 2.8 | 4.8-55 | <.0001 | 2.9 | 2.3-28 | .0001 | |||
| 3 | 13.3 | 6.6 | |||||||
| dFLC ≥18 mg/dL | 1.5 | 0.9-2.6 | .11 | ||||||
| ASCT at first line | 0.1 | 0.05-0.3 | <.0001 | 0.3 | 0.1-0.6 | .0005 |
CI, confidence interval; HR, hazard ratio.