Multivariate analysis for EFS and OS
| . | EFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| PB vs BM | 1.93 (0.87-4.26) | .104 | 2.62 (1.17-5.89) | .019 |
| CB vs BM | 0.55 (0.13-2.31) | .412 | Not applicable* | |
| Age | 1.09 (1.05-1.12) | <.001 | 1.10 (1.06-1.14) | <.0001 |
| Transplant year, ≥2007 vs ≤2006 | 0.95 (0.90-0.99) | .013 | 0.96 (0.91-1.00) | .101 |
| Conditioning regimen, RIC vs MAC | 1.13 (0.46-2.81) | .793 | 0.83 (0.29-2.39) | .735 |
| In vivo T-cell depletion, yes vs no | 1.34 (0.63-2.82) | .445 | 1.10 (0.49-2.48) | .806 |
| . | EFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| PB vs BM | 1.93 (0.87-4.26) | .104 | 2.62 (1.17-5.89) | .019 |
| CB vs BM | 0.55 (0.13-2.31) | .412 | Not applicable* | |
| Age | 1.09 (1.05-1.12) | <.001 | 1.10 (1.06-1.14) | <.0001 |
| Transplant year, ≥2007 vs ≤2006 | 0.95 (0.90-0.99) | .013 | 0.96 (0.91-1.00) | .101 |
| Conditioning regimen, RIC vs MAC | 1.13 (0.46-2.81) | .793 | 0.83 (0.29-2.39) | .735 |
| In vivo T-cell depletion, yes vs no | 1.34 (0.63-2.82) | .445 | 1.10 (0.49-2.48) | .806 |
The adjusted Cox regression analysis was stratified by registry (EBMT and CIBMTR); age was considered as a continuous variable, and when considering the graft source, PB and CB were compared, separately, with BM (baseline) for the EFS.
Not evaluable, as there was only 1 event in the CB group; therefore, for OS, the CB transplants were included with BM transplants.