Complications of antenatal treatment
| Reference . | AEs in FBS/IUPT n/N (%)* . | Complications after FBS or IUPT (n) . | SEs in IVIG n/N (%)* . | Reported SEs in IVIG treatment (n) . | SEs in steroids n/N (%)* . | Reported SEs in steroid treatment (n) . | |
|---|---|---|---|---|---|---|---|
| 24 | 1/9 (11) | Emergency CS due to fetal distress (1); <34 wk (0) | NR | NR | NR | NR | |
| 19 | 4/37 (11) | Emergency CS or delivery (4); <34 wk (NR); due to fetal distress (3); insertion bleeding (1) | NR | NR | NR | NR | |
| 34 | 3/99 (3) | Perinatal death (1); emergency CS due to fetal distress (3); <34 wk (0) | NR | NR | NA | NA | |
| 37 | 4/74 (5) | Emergency CS (4); <34 wk (3); due to fetal distress (2); PROM (2) | NR | Rash (1) discontinued IVIG, headache, fatigue† | NR | Gestational diabetes (7), insomnia, mood swings† | |
| 35 | 11/79 (14) | Fetal death (1); neonatal death (1); emergency CS or delivery (10); <34 wk (NR); due to fetal distress (8); streaming (1); PROM (1) | NR | NR | NR | NR | |
| 18 | 2/40 (5) | Neonatal death after fetal distress (1); emergency CS due to exsanguination (1) | NR | NR | NR | NR | |
| 28 | 15/38 (39) | Fetal death (2); after exsanguination (1); emergency CS/delivery (13); <34 wk (6); due to fetal distress (6), infection (1), technical difficulties (3), cord spasm or thrombosis (2), placental artery bleeding (1) | 1/18 (6) | Headache and tachycardia (1), continued IVIG | NR | NR | |
| 23 | 2/10 (20) | Emergency CS due to insertion bleeding (2), <34 wk (1) | NR | NR | NA | NA | |
| 42 | 4/15 (27) | Emergency CS or delivery (4); <34 wk (1); due to fetal distress (3); acute amnionitis after ROM (1) | 1/11 (9) | Headache and tachycardia (1), continued IVIG | NR | NR | |
| 20 | 5/59 (9)‡ | Fetal or neonatal death after exsanguination (5)‡ | 0/54 | None | 2/26 (8) | Oligohydramnios (2) dexamethasone 1.5 mg - dexamethasone 4.5 mg | |
| 33 | 2/10 (20) | Pregnancy loss at 16 wk’s gestation (1); neonatal death due to chorioamnionitis at 25 wk (1); | 0/10 | None | NA | NA | |
| 40 | 1/15 (7) | fetal death due to cord hematoma (1) | NR | NR | NR | NR | |
| 22 | NR | NR | NR | NR | 5/9 (56) | Oligohydramnios (4) dexamethasone 5 mg | |
| Reference . | AEs in FBS/IUPT n/N (%)* . | Complications after FBS or IUPT (n) . | SEs in IVIG n/N (%)* . | Reported SEs in IVIG treatment (n) . | SEs in steroids n/N (%)* . | Reported SEs in steroid treatment (n) . | |
|---|---|---|---|---|---|---|---|
| 24 | 1/9 (11) | Emergency CS due to fetal distress (1); <34 wk (0) | NR | NR | NR | NR | |
| 19 | 4/37 (11) | Emergency CS or delivery (4); <34 wk (NR); due to fetal distress (3); insertion bleeding (1) | NR | NR | NR | NR | |
| 34 | 3/99 (3) | Perinatal death (1); emergency CS due to fetal distress (3); <34 wk (0) | NR | NR | NA | NA | |
| 37 | 4/74 (5) | Emergency CS (4); <34 wk (3); due to fetal distress (2); PROM (2) | NR | Rash (1) discontinued IVIG, headache, fatigue† | NR | Gestational diabetes (7), insomnia, mood swings† | |
| 35 | 11/79 (14) | Fetal death (1); neonatal death (1); emergency CS or delivery (10); <34 wk (NR); due to fetal distress (8); streaming (1); PROM (1) | NR | NR | NR | NR | |
| 18 | 2/40 (5) | Neonatal death after fetal distress (1); emergency CS due to exsanguination (1) | NR | NR | NR | NR | |
| 28 | 15/38 (39) | Fetal death (2); after exsanguination (1); emergency CS/delivery (13); <34 wk (6); due to fetal distress (6), infection (1), technical difficulties (3), cord spasm or thrombosis (2), placental artery bleeding (1) | 1/18 (6) | Headache and tachycardia (1), continued IVIG | NR | NR | |
| 23 | 2/10 (20) | Emergency CS due to insertion bleeding (2), <34 wk (1) | NR | NR | NA | NA | |
| 42 | 4/15 (27) | Emergency CS or delivery (4); <34 wk (1); due to fetal distress (3); acute amnionitis after ROM (1) | 1/11 (9) | Headache and tachycardia (1), continued IVIG | NR | NR | |
| 20 | 5/59 (9)‡ | Fetal or neonatal death after exsanguination (5)‡ | 0/54 | None | 2/26 (8) | Oligohydramnios (2) dexamethasone 1.5 mg - dexamethasone 4.5 mg | |
| 33 | 2/10 (20) | Pregnancy loss at 16 wk’s gestation (1); neonatal death due to chorioamnionitis at 25 wk (1); | 0/10 | None | NA | NA | |
| 40 | 1/15 (7) | fetal death due to cord hematoma (1) | NR | NR | NR | NR | |
| 22 | NR | NR | NR | NR | 5/9 (56) | Oligohydramnios (4) dexamethasone 5 mg | |
AE, adverse event; CS, cesarean section; CTG, cardiotocogram; NR, not reported; PROM, prelabor rupture of membranes; SE, side effect.
Number of reported complications (n) versus the total number of patients treated with this specific strategy (N).
Number of side effects reported; the total number of patients that reported a side effect is unclear.
The complications occurring during this study were reported in detail elsewhere.40