Terms used to describe concepts of tolerance
| Term . | Definition . |
|---|---|
| Immune resistance | Immune cell–mediated inflammatory effector response. Contributes to homeostasis by clearing infections and tumor cells. Disturbs homeostasis by inducing immunopathology. |
| Immune tolerance | Immune cell–mediated regulatory mechanisms to inhibit immune resistance/inflammation. Contributes to homeostasis by protecting against immunopathology. Disturbs homeostasis by preventing immune resistance responses where it might be beneficial. |
| Disease tolerance | Parenchymal tissue-specific mechanisms to protect against immunopathology in the context of infectious inflammation. |
| Tissue tolerance | Parenchymal tissue-specific mechanisms to protect against immunopathology in the context of sterile/noninfectious inflammation. |
| Term . | Definition . |
|---|---|
| Immune resistance | Immune cell–mediated inflammatory effector response. Contributes to homeostasis by clearing infections and tumor cells. Disturbs homeostasis by inducing immunopathology. |
| Immune tolerance | Immune cell–mediated regulatory mechanisms to inhibit immune resistance/inflammation. Contributes to homeostasis by protecting against immunopathology. Disturbs homeostasis by preventing immune resistance responses where it might be beneficial. |
| Disease tolerance | Parenchymal tissue-specific mechanisms to protect against immunopathology in the context of infectious inflammation. |
| Tissue tolerance | Parenchymal tissue-specific mechanisms to protect against immunopathology in the context of sterile/noninfectious inflammation. |