Table 1. Most common grade 3 or higher... | American Society of Hematology

Table 1.

Most common grade 3 or higher side effects of the PIs bortezomib, carfilzomib, ixazomib reported in pivotal trials

	Bortezomib		Carfilzomib		Ixazomib
Type of side effect	Vd (IV)³	Vd (SC)^5,7*	Kd⁷	KRd⁶	IxaRd⁸
Hematological, %
Anemia	10	10-12	14	18	9
Neutropenia	14	18	NR	30	23
Thrombocytopenia	29	9-13	9	17	19
Nonhematological, %
Peripheral neuropathy	8	5	1	3	2
Diarrhea	7	2-7	3	4	6
Constipation	2	1-2	1	<1	<1
Nausea	2	0-1	1	NR	2
Vomiting	3	1-2	1	NR	1
Fatigue	5	2-7	5	8	4
Dyspnea	5	2	5	3	NR
Cardiac disease†	NR	3	6	7	3
Arterial hypertension	NR	3	9	4	3
Rash	1	NR	NR	NR	5

	Bortezomib		Carfilzomib		Ixazomib
Type of side effect	Vd (IV)³	Vd (SC)^5,7*	Kd⁷	KRd⁶	IxaRd⁸
Hematological, %
Anemia	10	10-12	14	18	9
Neutropenia	14	18	NR	30	23
Thrombocytopenia	29	9-13	9	17	19
Nonhematological, %
Peripheral neuropathy	8	5	1	3	2
Diarrhea	7	2-7	3	4	6
Constipation	2	1-2	1	<1	<1
Nausea	2	0-1	1	NR	2
Vomiting	3	1-2	1	NR	1
Fatigue	5	2-7	5	8	4
Dyspnea	5	2	5	3	NR
Cardiac disease†	NR	3	6	7	3
Arterial hypertension	NR	3	9	4	3
Rash	1	NR	NR	NR	5

IxaRd, ixazomib plus lenalidomide plus dexamethasone; KRd, carfilzomib plus lenalidomide plus dexamethasone; NR, not reported; SC, subcutaneous; Vd, bortezomib plus dexamethasone.

Twenty-one percent in Dimopoulos et al⁷ received bortezomib IV.

†

Cardiac failure and ischemic heart disease.

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