Concentration of FIX measured in joint synovial fluid at 2 h after IV delivery of FIX concentrates
FIX concentrate . | IV dose (IU/kg) . | Plasma FIX concentration (ng/mL) . | Synovial fluid lavage FIX concentration* (ng/mL) . |
---|---|---|---|
rFIX | 250 | 3734 | 25 |
N9-GP | 250 | 5747 | 35 |
rFIX in plasma:rFIX in synovial fluid lavage (diluted)* | 149:1 | ||
N9-GP in plasma:N9-GP in synovial fluid lavage (diluted)* | 164:1 | ||
N9-GP:rFIX in plasma | 1.54 | ||
N9-GP:rFIX in synovial fluid | 1.4 |
FIX concentrate . | IV dose (IU/kg) . | Plasma FIX concentration (ng/mL) . | Synovial fluid lavage FIX concentration* (ng/mL) . |
---|---|---|---|
rFIX | 250 | 3734 | 25 |
N9-GP | 250 | 5747 | 35 |
rFIX in plasma:rFIX in synovial fluid lavage (diluted)* | 149:1 | ||
N9-GP in plasma:N9-GP in synovial fluid lavage (diluted)* | 164:1 | ||
N9-GP:rFIX in plasma | 1.54 | ||
N9-GP:rFIX in synovial fluid | 1.4 |
Lavage of the joint results in an estimated ∼10-fold dilution of the synovial fluid.