Table 2.

Concentration of FIX measured in joint synovial fluid at 2 h after IV delivery of FIX concentrates

FIX concentrateIV dose (IU/kg)Plasma FIX concentration (ng/mL)Synovial fluid lavage FIX concentration* (ng/mL)
rFIX 250 3734 25 
N9-GP 250 5747 35 
rFIX in plasma:rFIX in synovial fluid lavage (diluted)*   149:1 
N9-GP in plasma:N9-GP in synovial fluid lavage (diluted)*   164:1 
N9-GP:rFIX in plasma   1.54 
N9-GP:rFIX in synovial fluid   1.4 
FIX concentrateIV dose (IU/kg)Plasma FIX concentration (ng/mL)Synovial fluid lavage FIX concentration* (ng/mL)
rFIX 250 3734 25 
N9-GP 250 5747 35 
rFIX in plasma:rFIX in synovial fluid lavage (diluted)*   149:1 
N9-GP in plasma:N9-GP in synovial fluid lavage (diluted)*   164:1 
N9-GP:rFIX in plasma   1.54 
N9-GP:rFIX in synovial fluid   1.4 
*

Lavage of the joint results in an estimated ∼10-fold dilution of the synovial fluid.

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