Table 2. Multivariable Cox models of... | American Society of Hematology

Table 2.

Multivariable Cox models of risk factors for detection of multiple viruses

Covariate	≥2 viruses	≥3 viruses	≥4 viruses*
Covariate	aHR (95% CI)	aHR (95% CI)	aHR (95% CI)
Age ≤21 y			2.65 (1.46-4.81)†
Male	1.18 (1.04-1.33)‡
White
CMV donor or recipient positive	2.47 (1.91-3.19)†	3.10 (1.95-4.94)†
Donor related	0.93 (0.81-1.07)	1.00 (0.80-1.25)
HCT comorbidity index
Low	Ref	Ref
Intermediate	1.03 (0.86-1.24)	1.64 (1.22-2.22)†
High	1.07 (0.90-1.28)	1.13 (0.83-1.53)
Myeloablative conditioning		1.36 (1.11-1.67)†
HCT type
HLA-matched	Ref	Ref	Ref
HLA-mismatched	2.03 (1.75-2.37)†	3.32 (2.64-4.18)†	7.36 (4.13-13.1)†
Cord blood	2.60 (2.16-3.14)†	3.29 (2.46-4.40)†	3.45 (1.62-7.36)†
Acute GVHD grades 3-4	2.14 (1.54-2.97)†

Covariate	≥2 viruses	≥3 viruses	≥4 viruses*
Covariate	aHR (95% CI)	aHR (95% CI)	aHR (95% CI)
Age ≤21 y			2.65 (1.46-4.81)†
Male	1.18 (1.04-1.33)‡
White
CMV donor or recipient positive	2.47 (1.91-3.19)†	3.10 (1.95-4.94)†
Donor related	0.93 (0.81-1.07)	1.00 (0.80-1.25)
HCT comorbidity index
Low	Ref	Ref
Intermediate	1.03 (0.86-1.24)	1.64 (1.22-2.22)†
High	1.07 (0.90-1.28)	1.13 (0.83-1.53)
Myeloablative conditioning		1.36 (1.11-1.67)†
HCT type
HLA-matched	Ref	Ref	Ref
HLA-mismatched	2.03 (1.75-2.37)†	3.32 (2.64-4.18)†	7.36 (4.13-13.1)†
Cord blood	2.60 (2.16-3.14)†	3.29 (2.46-4.40)†	3.45 (1.62-7.36)†
Acute GVHD grades 3-4	2.14 (1.54-2.97)†

Ref, reference.

This model supported only 2 variables because of limited events. Myeloablative conditioning was also significant after adjustment for HCT type: aHR, 4.64; 95% CI, <0.001.

†

P ≤ .001; ‡P ≤ .01.

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