Multivariate analysis of TTP, including prognostic genetic alterations, IPI, and DPE
| COO subtype, model, and variables . | HR (95% CI) . | P value . |
|---|---|---|
| ABC-DLBCL | ||
| Model 1 | ||
| BCL2 Gain/AMP (+ vs −) | 1.9 (1.1-3.4) | .03 |
| IPI (high, 3-5 vs low, 0-2) | 2.0 (1.1-3.6) | .02 |
| DPE (+ vs −) | 1.1 (0.6-1.9) | .81 |
| Model 2 | ||
| MYC TR (+ vs −) | 1.6 (0.7-3.5) | .23 |
| IPI (high, 3-5 vs low, 0-2) | 2.0 (1.2-3.6) | .01 |
| DPE (+ vs −) | 1.2 (0.7-2.2) | .51 |
| GCB-DLBCL | ||
| Model 1 | ||
| BCL2 TR (+ vs −) | 2.4 (1.2-4.3) | .02 |
| IPI (high, 3-5 vs low, 0-2) | 3.5 (1.8-6.6) | <.001 |
| DPE (+ vs −) | 1.5 (0.7-3.2) | .27 |
| Model 2 | ||
| MYC TR (+ vs −) | 1.9 (0.9-4.0) | .10 |
| IPI (high, 3-5 vs low, 0-2) | 4.4 (2.3-8.2) | <.001 |
| DPE (+ vs −) | 1.8 (0.9-3.8) | .12 |
| Model 3 | ||
| BCL2 Gain/AMP (+ vs −) | 2.1 (0.97-4.4) | .06 |
| IPI (high, 3-5 vs low, 0-2) | 4.3 (2.3-8.1) | <.001 |
| DPE (+ vs −) | 2.2 (1.1-4.5) | .02 |
| Model 4 | ||
| MYC Gain/AMP (+ vs −) | 1.8 (0.9-3.4) | .08 |
| IPI (high, 3-5 vs low, 0-2) | 4.2 (2.2-7.7) | <.001 |
| DPE (+ vs −) | 2.3 (1.1-4.5) | .02 |
| COO subtype, model, and variables . | HR (95% CI) . | P value . |
|---|---|---|
| ABC-DLBCL | ||
| Model 1 | ||
| BCL2 Gain/AMP (+ vs −) | 1.9 (1.1-3.4) | .03 |
| IPI (high, 3-5 vs low, 0-2) | 2.0 (1.1-3.6) | .02 |
| DPE (+ vs −) | 1.1 (0.6-1.9) | .81 |
| Model 2 | ||
| MYC TR (+ vs −) | 1.6 (0.7-3.5) | .23 |
| IPI (high, 3-5 vs low, 0-2) | 2.0 (1.2-3.6) | .01 |
| DPE (+ vs −) | 1.2 (0.7-2.2) | .51 |
| GCB-DLBCL | ||
| Model 1 | ||
| BCL2 TR (+ vs −) | 2.4 (1.2-4.3) | .02 |
| IPI (high, 3-5 vs low, 0-2) | 3.5 (1.8-6.6) | <.001 |
| DPE (+ vs −) | 1.5 (0.7-3.2) | .27 |
| Model 2 | ||
| MYC TR (+ vs −) | 1.9 (0.9-4.0) | .10 |
| IPI (high, 3-5 vs low, 0-2) | 4.4 (2.3-8.2) | <.001 |
| DPE (+ vs −) | 1.8 (0.9-3.8) | .12 |
| Model 3 | ||
| BCL2 Gain/AMP (+ vs −) | 2.1 (0.97-4.4) | .06 |
| IPI (high, 3-5 vs low, 0-2) | 4.3 (2.3-8.1) | <.001 |
| DPE (+ vs −) | 2.2 (1.1-4.5) | .02 |
| Model 4 | ||
| MYC Gain/AMP (+ vs −) | 1.8 (0.9-3.4) | .08 |
| IPI (high, 3-5 vs low, 0-2) | 4.2 (2.2-7.7) | <.001 |
| DPE (+ vs −) | 2.3 (1.1-4.5) | .02 |
Bold indicates significance.
CI, confidence interval; Gain/AMP: gain and/or amplification; HR, hazard ratio; TR, translocation.