Table 3.

Univariate association of CNA presence

CNAs, nPatients, nOS ± 2 × SE, %*PEFS ± 2 × SE, %*PDFS ± 2 × SE, %†P
Overall   .007  .064  .050 
 0 191 73 ± 7  54 ± 7  58 ± 8  
 1+ 255 62 ± 6  46 ± 6  50 ± 7  
Favorable risk   .321  .641  .805 
 0 92 86 ± 7  65 ± 10  65 ± 11  
 1+ 102 82 ± 8  64 ± 10  64 ± 10  
Standard risk   .016  .075  .102 
 0 64 66 ± 12  46 ± 13  48 ± 15  
 1+ 115 47 ± 10  34 ± 9  37 ± 10  
Poor risk   .167  .409  .214 
 0 28 55 ± 20  37 ± 19  51 ± 23  
 1+ 31 45 ± 18  32 ± 17  43 ± 22  
CNAs, nPatients, nOS ± 2 × SE, %*PEFS ± 2 × SE, %*PDFS ± 2 × SE, %†P
Overall   .007  .064  .050 
 0 191 73 ± 7  54 ± 7  58 ± 8  
 1+ 255 62 ± 6  46 ± 6  50 ± 7  
Favorable risk   .321  .641  .805 
 0 92 86 ± 7  65 ± 10  65 ± 11  
 1+ 102 82 ± 8  64 ± 10  64 ± 10  
Standard risk   .016  .075  .102 
 0 64 66 ± 12  46 ± 13  48 ± 15  
 1+ 115 47 ± 10  34 ± 9  37 ± 10  
Poor risk   .167  .409  .214 
 0 28 55 ± 20  37 ± 19  51 ± 23  
 1+ 31 45 ± 18  32 ± 17  43 ± 22  

COG cohort (n = 466). Mantel-Cox log-rank P value is used to denote significance. CNA presence is defined as the presence of any CNA in the tumor genome (dichotomous). The reference category is no CNA presence (CNA = 0).

*

OS and EFS from study entry.

†

DFS after induction 1.

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