Table 1.

Demographic data of 46 patients treated with R-LEN

CharacteristicsNo. of patients
Total patients 46 
Female 28 (61%) 
Male 18 (39%) 
Median age, y (range) 64 (32-84) 
Primary localization of MALT lymphoma  
 Stomach 14 (30%) 
 Ocular adnexa 13 (28%) 
 Lung 5 (11%) 
 Parotid gland 3 (7%) 
 Other 6 (13%) 
 Multiple extranodal sites 5 (11%) 
Current site of lymphoma/site of relapse  
 Stomach 10 (22%) 
 Ocular adnexa 12 (26%) 
 Lung 4 (9%) 
 Other 8 (17%) 
 Multiple extranodal sites 12 (26%) 
Stage according to Ann Arbor  
 I/IIE “localized disease” 28 (61%) 
 III/IVE “disseminated disease” 18 (39%) 
ECOG performance status  
 ECOG 0-1 45 (98%) 
 ECOG 2 1 (2%) 
LDH elevation at baseline 6 (13%) 
IPI Score  
 0-2 37 (80%) 
 >2 9 (20%) 
Prior treatment  
 Systemic (immuno-/chemotherapy) 11 (24%) 
 R-containing regimens 9 (20%) 
 Prior lenalidomide treatment 1 (2%) 
 >2 prior treatment lines 9 (20%) 
Median follow-up time in months (range) 27.0 (13.2-36.3) 
CharacteristicsNo. of patients
Total patients 46 
Female 28 (61%) 
Male 18 (39%) 
Median age, y (range) 64 (32-84) 
Primary localization of MALT lymphoma  
 Stomach 14 (30%) 
 Ocular adnexa 13 (28%) 
 Lung 5 (11%) 
 Parotid gland 3 (7%) 
 Other 6 (13%) 
 Multiple extranodal sites 5 (11%) 
Current site of lymphoma/site of relapse  
 Stomach 10 (22%) 
 Ocular adnexa 12 (26%) 
 Lung 4 (9%) 
 Other 8 (17%) 
 Multiple extranodal sites 12 (26%) 
Stage according to Ann Arbor  
 I/IIE “localized disease” 28 (61%) 
 III/IVE “disseminated disease” 18 (39%) 
ECOG performance status  
 ECOG 0-1 45 (98%) 
 ECOG 2 1 (2%) 
LDH elevation at baseline 6 (13%) 
IPI Score  
 0-2 37 (80%) 
 >2 9 (20%) 
Prior treatment  
 Systemic (immuno-/chemotherapy) 11 (24%) 
 R-containing regimens 9 (20%) 
 Prior lenalidomide treatment 1 (2%) 
 >2 prior treatment lines 9 (20%) 
Median follow-up time in months (range) 27.0 (13.2-36.3) 

IPI, International Prognostic Index.

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