Table 2. Megakaryocyte/platelet ITIM and... | American Society of Hematology

Table 2.

Megakaryocyte/platelet ITIM and ITSM receptor sequences

Receptor	Human			Mouse
Receptor	ITIM	ITSM	Nonconsensus ITIM/ITSM	ITIM	ITSM	Nonconsensus ITIM/ITSM
PECAM-1	VQY₆₆₃TEV	TVY₆₈₆SEV		VEY₆₆₂TEV	TVY₆₈₅SEI
G6b-B	LLY₁₉₄ADL	TIY₂₂₀AVV		LHY₁₉₅ADL	TVY₂₂₁AVV
TLT-1	VTY₂₆₆ATV		TTY₂₃₀TSL	VTY₂₆₆ATV		SIY₂₃₂TGS
CEACAM1	VTY₄₅₉STL			VAY₄₅₄TVL	TVY₄₈₁SEV
CEACAM1	IIY₄₈₆SEV			VAY₄₅₄TVL	TVY₄₈₁SEV
CEACAM2				VAY₂₇₃TVL	TVY₃₀₀SEV
LILRB2 (PIR-B)	VTY₅₄₁AQL		NLY₅₁₂AAV	VTY₇₇₀AQL		SLY₆₈₉ASV
			SIY₅₇₁ATL			TEY₇₄₆EQA
						SVY₈₀₀ATL
LAIR-1	VTY₂₃₀AQL			VTY₂₀₇IQL	STY₂₃₆AAI
LAIR-1	ITY₂₆₀AAV			VTY₂₀₇IQL	STY₂₃₆AAI
CD84		TIY₂₅₈TYI			TVY₂₄₄AVV
CD84		TVY₂₉₅SEV			TIY₂₇₉SSV
CD150		TIY₂₆₁AQV	TIY₂₈₇VAA		TIY₂₆₄AQV	TIY₂₉₁VAA
CD150		TVY₃₀₇ASV	TIY₂₈₇VAA		TVY₃₁₁ASV	TIY₂₉₁VAA

Receptor	Human			Mouse
Receptor	ITIM	ITSM	Nonconsensus ITIM/ITSM	ITIM	ITSM	Nonconsensus ITIM/ITSM
PECAM-1	VQY₆₆₃TEV	TVY₆₈₆SEV		VEY₆₆₂TEV	TVY₆₈₅SEI
G6b-B	LLY₁₉₄ADL	TIY₂₂₀AVV		LHY₁₉₅ADL	TVY₂₂₁AVV
TLT-1	VTY₂₆₆ATV		TTY₂₃₀TSL	VTY₂₆₆ATV		SIY₂₃₂TGS
CEACAM1	VTY₄₅₉STL			VAY₄₅₄TVL	TVY₄₈₁SEV
CEACAM1	IIY₄₈₆SEV			VAY₄₅₄TVL	TVY₄₈₁SEV
CEACAM2				VAY₂₇₃TVL	TVY₃₀₀SEV
LILRB2 (PIR-B)	VTY₅₄₁AQL		NLY₅₁₂AAV	VTY₇₇₀AQL		SLY₆₈₉ASV
			SIY₅₇₁ATL			TEY₇₄₆EQA
						SVY₈₀₀ATL
LAIR-1	VTY₂₃₀AQL			VTY₂₀₇IQL	STY₂₃₆AAI
LAIR-1	ITY₂₆₀AAV			VTY₂₀₇IQL	STY₂₃₆AAI
CD84		TIY₂₅₈TYI			TVY₂₄₄AVV
CD84		TVY₂₉₅SEV			TIY₂₇₉SSV
CD150		TIY₂₆₁AQV	TIY₂₈₇VAA		TIY₂₆₄AQV	TIY₂₉₁VAA
CD150		TVY₃₀₇ASV	TIY₂₈₇VAA		TVY₃₁₁ASV	TIY₂₉₁VAA

ITIM consensus: I/V/LxYxxL/V; ITSM consensus: TxYxxV/I. Conserved tyrosine residues (shown in bold) are numbered according to the mature protein after cleavage of the signal peptide.