Categories of rFVIII
| Generation . | Trade name . | Manufacturer . | Cell line . | Protein length . | Albumin use . | Stabilizer . |
|---|---|---|---|---|---|---|
| 1 | Recombinate | Baxalta/Shire Bioscience | CHO | Full | Cell culture (human) | Bovine albumin |
| 2 | Kogenate FS | Bayer Healthcare | BHK | Full | Cell culture (human) | Sucrose |
| Helixate FS | BHK | Full | Sucrose | |||
| Refacto | Pfizer | CHO | B-domain deleted | Sucrose | ||
| 3 | Advate | Baxalta/Shire Bioscience | CHO | Full | No | No |
| Xyntha | Pfizer | CHO | B-domain deleted | No | No |
| Generation . | Trade name . | Manufacturer . | Cell line . | Protein length . | Albumin use . | Stabilizer . |
|---|---|---|---|---|---|---|
| 1 | Recombinate | Baxalta/Shire Bioscience | CHO | Full | Cell culture (human) | Bovine albumin |
| 2 | Kogenate FS | Bayer Healthcare | BHK | Full | Cell culture (human) | Sucrose |
| Helixate FS | BHK | Full | Sucrose | |||
| Refacto | Pfizer | CHO | B-domain deleted | Sucrose | ||
| 3 | Advate | Baxalta/Shire Bioscience | CHO | Full | No | No |
| Xyntha | Pfizer | CHO | B-domain deleted | No | No |