Table 1. Main associated clinical... | American Society of Hematology

Table 1.

Main associated clinical contexts identified at the initial acute episode of TTP in reports involving more than 50 patients (both adults and children)

Series (year)	USS, %	Idiopathic, %	Infection* and HIV, %	Autoimmune disease, %	Cancer and/or organ/HSPC transplant, %	Pregnancy and postpartum, %	Other, %	Drugs, %
Scully et al (2008)³ [N = 176]	5	77	<1 and 7	—	2	5†	4	<1
Kremer Hovinga et al (2010), Deford et al (2013)^6,8 [N = 60]	0	77	7	5	2 and 2	5	3	0
Lotta et al (2010)⁴ [N = 136]	0	79	0	7	0	9	1	4
Fujimura et al (2010)⁵ [N = 326]	12	60	0	14	2 and 0	1	4	7
Jang et al (2011)⁷ [N = 66]	0	59	9	6	8 and 1	6	3	8
Blombery et al (2016)⁹ [N = 57]	0	75	3 and 0	18	0	2	0	2
Coppo et al (2016)¹⁰ [N = 772]	3	49	12 and 3	11	9 and 4	5	3	1

Series (year)	USS, %	Idiopathic, %	Infection* and HIV, %	Autoimmune disease, %	Cancer and/or organ/HSPC transplant, %	Pregnancy and postpartum, %	Other, %	Drugs, %
Scully et al (2008)³ [N = 176]	5	77	<1 and 7	—	2	5†	4	<1
Kremer Hovinga et al (2010), Deford et al (2013)^6,8 [N = 60]	0	77	7	5	2 and 2	5	3	0
Lotta et al (2010)⁴ [N = 136]	0	79	0	7	0	9	1	4
Fujimura et al (2010)⁵ [N = 326]	12	60	0	14	2 and 0	1	4	7
Jang et al (2011)⁷ [N = 66]	0	59	9	6	8 and 1	6	3	8
Blombery et al (2016)⁹ [N = 57]	0	75	3 and 0	18	0	2	0	2
Coppo et al (2016)¹⁰ [N = 772]	3	49	12 and 3	11	9 and 4	5	3	1

HIV, human immunodeficiency virus; HPSC, hematopoietic stem-cell; N, number of patients.

Specific diagnosis made.

†

Pregnancy and combined oral contraceptive pill.

View Large

This Feature Is Available To Subscribers Only