Average annual change in graded exercise performance over the course of 20 years by sickle cell trait status
| . | No. . | Baseline mean (95% CI) . | Mean change/year (95% CI) . | Mean change/year (95% CI), relative to No SCT . | P value* . |
|---|---|---|---|---|---|
| Test duration , sec | |||||
| No SCT | 1402 | 540.4 (535.0-545.8) | −9.12 (−9.50 to −8.75) | Reference | |
| SCT | 101 | 540.8 (520.6-561.1) | −8.71 (−10.10 to −7.32) | 0.41 (−1.03 to 1.85) | .58 |
| Estimated METs | |||||
| No SCT | 1402 | 11.7 (11.6-11.8) | −0.12 (−0.13 to −0.11) | Reference | |
| SCT | 101 | 11.8 (11.5-12.1) | −0.12 (−0.15 to −0.10) | 0.00 (−0.03 to 0.02) | .82 |
| Maximum HR, beats/min | |||||
| No SCT | 1402 | 176.1 (175.2-177.0) | −0.56 (−0.61 to −0.51) | Reference | |
| SCT | 101 | 174.7 (171.4-177.9) | −0.46 (−0.71 to −0.20) | 0.10 (−0.10 to 0.30) | .34 |
| HR recovery at 2 min, beats/min | |||||
| No SCT | 1390 | 43.2 (42.6-43.8) | −0.25 (−0.28 to −0.21) | Reference | |
| SCT | 101 | 44.5 (42.3-46.6) | −0.24 (−0.39 to −0.09) | 0.01 (−0.15 to 0.16) | .94 |
| . | No. . | Baseline mean (95% CI) . | Mean change/year (95% CI) . | Mean change/year (95% CI), relative to No SCT . | P value* . |
|---|---|---|---|---|---|
| Test duration , sec | |||||
| No SCT | 1402 | 540.4 (535.0-545.8) | −9.12 (−9.50 to −8.75) | Reference | |
| SCT | 101 | 540.8 (520.6-561.1) | −8.71 (−10.10 to −7.32) | 0.41 (−1.03 to 1.85) | .58 |
| Estimated METs | |||||
| No SCT | 1402 | 11.7 (11.6-11.8) | −0.12 (−0.13 to −0.11) | Reference | |
| SCT | 101 | 11.8 (11.5-12.1) | −0.12 (−0.15 to −0.10) | 0.00 (−0.03 to 0.02) | .82 |
| Maximum HR, beats/min | |||||
| No SCT | 1402 | 176.1 (175.2-177.0) | −0.56 (−0.61 to −0.51) | Reference | |
| SCT | 101 | 174.7 (171.4-177.9) | −0.46 (−0.71 to −0.20) | 0.10 (−0.10 to 0.30) | .34 |
| HR recovery at 2 min, beats/min | |||||
| No SCT | 1390 | 43.2 (42.6-43.8) | −0.25 (−0.28 to −0.21) | Reference | |
| SCT | 101 | 44.5 (42.3-46.6) | −0.24 (−0.39 to −0.09) | 0.01 (−0.15 to 0.16) | .94 |
Fitness testing was performed at years 7 and 20. Analysis sample included participants with fitness data available at baseline and at least 1 more exam at year 7 or year 20. Models were adjusted for sex, baseline age, physical activity, and BMI.
SCT, sickle cell trait carrier status.
P values for comparisons between SCT and No SCT (reference).