Findings that should prompt evaluation for cryoglobulinemia
| Clinical signs . | Laboratory findings . | Histopathologic findings . |
|---|---|---|
| Skin purpura | Unexplained hypocomplementemia (especially low C4) | Leukocytoclastic vasculitis |
| Livedo reticularis | Unexplained increased RF activity | Membranoproliferative glomerulonephritis |
| Raynaud’s phenomenon | Positive hepatitis C virus | Small vessel hyaline thrombi |
| Acrocyanosis | Red blood cell urine casts | |
| Cutaneous ischemia and ulcers | Proteinuria ± active sediment | |
| Arthralgia and arthritis | ||
| Peripheral neuropathy | ||
| Cold sensitivity, especially in patients with a monoclonal gammopathy |
| Clinical signs . | Laboratory findings . | Histopathologic findings . |
|---|---|---|
| Skin purpura | Unexplained hypocomplementemia (especially low C4) | Leukocytoclastic vasculitis |
| Livedo reticularis | Unexplained increased RF activity | Membranoproliferative glomerulonephritis |
| Raynaud’s phenomenon | Positive hepatitis C virus | Small vessel hyaline thrombi |
| Acrocyanosis | Red blood cell urine casts | |
| Cutaneous ischemia and ulcers | Proteinuria ± active sediment | |
| Arthralgia and arthritis | ||
| Peripheral neuropathy | ||
| Cold sensitivity, especially in patients with a monoclonal gammopathy |