Table 3. Multipredictor models of... | American Society of Hematology

Table 3.

Multipredictor models of laboratory predictors of grade ≥2A bleeding, taking into account within-person correlation

Predictor	Model 1*			Model 2†
Predictor	OR	95% CI	P	OR	95% CI	P
Stratum			<.001			<.001
ALLO	1.00	Ref.		1.00	Ref.
AUTO	0.44	0.34-0.56	<.001	0.38	0.26-0.55	<.001
CHEMO	0.55	0.43-0.71	<.001	0.55	0.39-0.77	<.001
Platelet count, ×10⁹/L			<.001			.55
1-5	2.96	1.93-4.54	<.001	1.79	0.86-3.75	.12
6-10	2.02	1.41-2.87	<.001	1.62	0.98-2.68	.06
11-15	2.34	1.65-3.33	<.001	1.61	0.95-2.72	.08
16-20	2.21	1.56-3.13	<.001	1.62	0.94-2.78	.08
21-25	1.96	1.37-2.79	<.001	1.52	0.91-2.54	.11
26-30	1.89	1.33-2.68	<.001	1.86	1.12-3.09	.02
31-35	2.06	1.45-2.94	<.001	1.68	0.96-2.94	.07
36-40	1.82	1.26-2.63	.001	1.50	0.86-2.61	.16
41-45	1.91	1.33-2.74	<.001	1.57	0.89-2.75	.12
46-50	2.01	1.33-3.04	<.001	1.81	0.97-3.37	.06
51-55	2.10	1.38-3.19	<.001	1.76	0.96-3.23	.07
56-60	1.82	1.18-2.80	.01	1.56	0.78-3.12	.21
61-65	1.25	0.74-2.10	.41	0.91	0.41-2.01	.82
66-70	2.54	1.60-4.02	<.001	2.28	0.97-5.34	.06
71-75	1.64	0.91-2.98	.10	0.96	0.41-2.25	.93
76-80	1.67	0.91-3.04	.10	1.46	0.60-3.55	.40
81+	1.00	Ref.		1.00	Ref.
Hematocrit, %			.02			.35
≤25	1.20	1.03-1.39	.02	1.08	0.84-1.38	.56
26-29	1.06	0.94-1.19	.36	0.93	0.74-1.18	.57
>29	1.00	Ref.		1.00	Ref.
aPTT						.04
≤30				1.00	Ref.
31-50				1.17	0.90-1.52	.24
>50				1.90	1.24-2.91	.003
INR						.01
≤1.2				1.00	Ref.
1.3-1.5				1.35	1.06-1.71	.01
>1.5				1.79	1.28-2.52	<.001

Predictor	Model 1*			Model 2†
Predictor	OR	95% CI	P	OR	95% CI	P
Stratum			<.001			<.001
ALLO	1.00	Ref.		1.00	Ref.
AUTO	0.44	0.34-0.56	<.001	0.38	0.26-0.55	<.001
CHEMO	0.55	0.43-0.71	<.001	0.55	0.39-0.77	<.001
Platelet count, ×10⁹/L			<.001			.55
1-5	2.96	1.93-4.54	<.001	1.79	0.86-3.75	.12
6-10	2.02	1.41-2.87	<.001	1.62	0.98-2.68	.06
11-15	2.34	1.65-3.33	<.001	1.61	0.95-2.72	.08
16-20	2.21	1.56-3.13	<.001	1.62	0.94-2.78	.08
21-25	1.96	1.37-2.79	<.001	1.52	0.91-2.54	.11
26-30	1.89	1.33-2.68	<.001	1.86	1.12-3.09	.02
31-35	2.06	1.45-2.94	<.001	1.68	0.96-2.94	.07
36-40	1.82	1.26-2.63	.001	1.50	0.86-2.61	.16
41-45	1.91	1.33-2.74	<.001	1.57	0.89-2.75	.12
46-50	2.01	1.33-3.04	<.001	1.81	0.97-3.37	.06
51-55	2.10	1.38-3.19	<.001	1.76	0.96-3.23	.07
56-60	1.82	1.18-2.80	.01	1.56	0.78-3.12	.21
61-65	1.25	0.74-2.10	.41	0.91	0.41-2.01	.82
66-70	2.54	1.60-4.02	<.001	2.28	0.97-5.34	.06
71-75	1.64	0.91-2.98	.10	0.96	0.41-2.25	.93
76-80	1.67	0.91-3.04	.10	1.46	0.60-3.55	.40
81+	1.00	Ref.		1.00	Ref.
Hematocrit, %			.02			.35
≤25	1.20	1.03-1.39	.02	1.08	0.84-1.38	.56
26-29	1.06	0.94-1.19	.36	0.93	0.74-1.18	.57
>29	1.00	Ref.		1.00	Ref.
aPTT						.04
≤30				1.00	Ref.
31-50				1.17	0.90-1.52	.24
>50				1.90	1.24-2.91	.003
INR						.01
≤1.2				1.00	Ref.
1.3-1.5				1.35	1.06-1.71	.01
>1.5				1.79	1.28-2.52	<.001

OR, odds ratio; Ref., reference.

Grade ≥2A bleeding days/total days = 2403/15 979 = 15%.

Grade ≥2A bleeding days/total days = 612/3,604 = 17%.