Side effects of BRAF and MEK inhibitors
| . | Vemurafenib, n (%) . | Cobimetinib, n (%) . |
|---|---|---|
| Photosensibility, pilar keratosis | 16 (32) | — |
| Acne rash | — | 8 (53) |
| DRESS | 2 (4) | — |
| DRESS-like* | 1 (2) | — |
| Cutaneous allergy | 1 (2) | 1 (7) |
| Spinocellular carcinoma | 4 (8) | — |
| Basocellular carcinoma | 3 (6) | — |
| Melanoma | 1 (5) | — |
| Actinic keratosis | 2 (4) | — |
| Bowen disease | 1 (2) | — |
| Multiple nevi | 3 (6) | — |
| Eyelid keratoacanthoma | 1 (2) | — |
| Nausea, vomiting | 1 (2) | 4 (27) |
| Arthralgia | 7 (14) | — |
| Renal vasculitis | 1 (2) | — |
| Tuberculosis | 1 (2) | — |
| Deep vein thrombosis | 1 (2) | — |
| Neutropenia | 1 (2) | — |
| Scotoma and syncope | 1 (2), combination therapy; ophthalmic examination was normal, and electrocardiogram and electrophysiological studies were also normal | |
| QT prolongation, torsade de pointes and cardiac arrest | 1, treatment was resumed after ICD implantation (2) | — |
| Gastric cancer | 1 (no RAF or RAS mutation) (2) | — |
| Cardiac failure | 1 case, reversible when the dose was tapered (2) | — |
| Hypertriglyceridemia | 1 (2) | — |
| Depressive episode | 1 (2) | — |
| Rhabdomyolysis | — | 4 (27) |
| Sarcoidosis-like disease | 3 (6) | — |
| . | Vemurafenib, n (%) . | Cobimetinib, n (%) . |
|---|---|---|
| Photosensibility, pilar keratosis | 16 (32) | — |
| Acne rash | — | 8 (53) |
| DRESS | 2 (4) | — |
| DRESS-like* | 1 (2) | — |
| Cutaneous allergy | 1 (2) | 1 (7) |
| Spinocellular carcinoma | 4 (8) | — |
| Basocellular carcinoma | 3 (6) | — |
| Melanoma | 1 (5) | — |
| Actinic keratosis | 2 (4) | — |
| Bowen disease | 1 (2) | — |
| Multiple nevi | 3 (6) | — |
| Eyelid keratoacanthoma | 1 (2) | — |
| Nausea, vomiting | 1 (2) | 4 (27) |
| Arthralgia | 7 (14) | — |
| Renal vasculitis | 1 (2) | — |
| Tuberculosis | 1 (2) | — |
| Deep vein thrombosis | 1 (2) | — |
| Neutropenia | 1 (2) | — |
| Scotoma and syncope | 1 (2), combination therapy; ophthalmic examination was normal, and electrocardiogram and electrophysiological studies were also normal | |
| QT prolongation, torsade de pointes and cardiac arrest | 1, treatment was resumed after ICD implantation (2) | — |
| Gastric cancer | 1 (no RAF or RAS mutation) (2) | — |
| Cardiac failure | 1 case, reversible when the dose was tapered (2) | — |
| Hypertriglyceridemia | 1 (2) | — |
| Depressive episode | 1 (2) | — |
| Rhabdomyolysis | — | 4 (27) |
| Sarcoidosis-like disease | 3 (6) | — |
ICD, implantable cardioverter-defibrillator.
Cholestasis and eosinophilia were reversible after treatment was stopped.