Univariate and multivariate analysis for OS (overall population)
| Variable . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age | 1.948 | 0.590-6.438 | .274 | |||
| ≤60 y | ||||||
| >60 y | ||||||
| WHO diagnosis | 1.343 | 0.594-3.034 | .478 | |||
| MDS | ||||||
| MDS/MPN | ||||||
| Cytopenias | 2.230 | 1.015-4.899 | .046 | 4.197 | 0.340-51.865 | .264 |
| 0-1 | ||||||
| ≥2 | ||||||
| BM blasts | 1.393 | 0.657-2.957 | .387 | |||
| <5% | ||||||
| ≥5 | ||||||
| Cytogenetic risk | 0.500 | 0.213-1.170 | .110 | |||
| Good | ||||||
| Others | ||||||
| Transfusion | 2.304 | 1.070-4.959 | .033 | 1.242 | 0.186-8.301 | .823 |
| Dependent | ||||||
| Independent | ||||||
| IPSS risk | 1.144 | 0.398-3.293 | .803 | |||
| Low | ||||||
| Intermediate 1 | ||||||
| IPSS-R risk | 1.263 | 0.519-3.188 | .406 | |||
| High or very high | ||||||
| Others | ||||||
| MDA LR-MDS score | 1.258 | 0.607-2.606 | .537 | |||
| High (category 3) | ||||||
| Others | ||||||
| Response | 0.378 | 0.161-0.890 | .026 | 0.045 | 0.002-0.995 | .047 |
| CR | ||||||
| Non-CR | ||||||
| DNMT3A | 5.719 | 1.621-20.181 | .007 | 25.930 | 0.904-743.842 | .057 |
| Wild-type | ||||||
| Mutated | ||||||
| TP53 | 3.682 | 1.228-11.035 | .020 | 136.764 | 5.292-3534.38 | .003 |
| Wild-type | ||||||
| Mutated | ||||||
| ZRSR2 | 45.475 | 2.843-727.310 | .007 | 94.865 | 2.528-3559.721 | .014 |
| Wild-type | ||||||
| Mutated | ||||||
| Variable . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age | 1.948 | 0.590-6.438 | .274 | |||
| ≤60 y | ||||||
| >60 y | ||||||
| WHO diagnosis | 1.343 | 0.594-3.034 | .478 | |||
| MDS | ||||||
| MDS/MPN | ||||||
| Cytopenias | 2.230 | 1.015-4.899 | .046 | 4.197 | 0.340-51.865 | .264 |
| 0-1 | ||||||
| ≥2 | ||||||
| BM blasts | 1.393 | 0.657-2.957 | .387 | |||
| <5% | ||||||
| ≥5 | ||||||
| Cytogenetic risk | 0.500 | 0.213-1.170 | .110 | |||
| Good | ||||||
| Others | ||||||
| Transfusion | 2.304 | 1.070-4.959 | .033 | 1.242 | 0.186-8.301 | .823 |
| Dependent | ||||||
| Independent | ||||||
| IPSS risk | 1.144 | 0.398-3.293 | .803 | |||
| Low | ||||||
| Intermediate 1 | ||||||
| IPSS-R risk | 1.263 | 0.519-3.188 | .406 | |||
| High or very high | ||||||
| Others | ||||||
| MDA LR-MDS score | 1.258 | 0.607-2.606 | .537 | |||
| High (category 3) | ||||||
| Others | ||||||
| Response | 0.378 | 0.161-0.890 | .026 | 0.045 | 0.002-0.995 | .047 |
| CR | ||||||
| Non-CR | ||||||
| DNMT3A | 5.719 | 1.621-20.181 | .007 | 25.930 | 0.904-743.842 | .057 |
| Wild-type | ||||||
| Mutated | ||||||
| TP53 | 3.682 | 1.228-11.035 | .020 | 136.764 | 5.292-3534.38 | .003 |
| Wild-type | ||||||
| Mutated | ||||||
| ZRSR2 | 45.475 | 2.843-727.310 | .007 | 94.865 | 2.528-3559.721 | .014 |
| Wild-type | ||||||
| Mutated | ||||||