Table 2. Multivariate Cox regression... | American Society of Hematology

Table 2.

Multivariate Cox regression analyses (n = 147)

Variables	OS			PFS			CIR
Variables	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
mut TP53	6.2	(2.6-14.9)	<.0001	6.8	(3.4-13.8)	<.0001	6.9	(3.3-14.5)	<.0001
mut NOTCH1	2.7	(0.9-8.6)	.09	2.3	(0.9-6.3)	.10	2.2	(0.7-6.5)	.17
del TP53	1.4	(0.7-2.8)	.37	1.5	(0.9-2.7)	.15	1.7	(0.9-3.0)	.10
del CDKN2A	1.3	(0.6-2.7)	.55	1.3	(0.7-2.4)	.40	1.3	(0.7-2.5)	.43
Blastoid	1.3	(0.6-2.5)	.53	0.8	(0.4-1.6)	.62	0.9	(0.4-1.7)	.65
MIPI-c high-risk*	1.8	(0.9-3.9)	.11	2.2	(1.2-4.0)	.01	2.6	(1.4-4.9)	.003
mut WHSC1†	0.8	(0.3-1.9)	.58	—	—	—	—	—	—

Variables	OS			PFS			CIR
Variables	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
mut TP53	6.2	(2.6-14.9)	<.0001	6.8	(3.4-13.8)	<.0001	6.9	(3.3-14.5)	<.0001
mut NOTCH1	2.7	(0.9-8.6)	.09	2.3	(0.9-6.3)	.10	2.2	(0.7-6.5)	.17
del TP53	1.4	(0.7-2.8)	.37	1.5	(0.9-2.7)	.15	1.7	(0.9-3.0)	.10
del CDKN2A	1.3	(0.6-2.7)	.55	1.3	(0.7-2.4)	.40	1.3	(0.7-2.5)	.43
Blastoid	1.3	(0.6-2.5)	.53	0.8	(0.4-1.6)	.62	0.9	(0.4-1.7)	.65
MIPI-c high-risk*	1.8	(0.9-3.9)	.11	2.2	(1.2-4.0)	.01	2.6	(1.4-4.9)	.003
mut WHSC1†	0.8	(0.3-1.9)	.58	—	—	—	—	—	—

MIPI-c index included as a bimodal variable of MIPI-c high-risk or not.

WHSC1 mutations only included for OS, as they did not show significant prognostic effect for PFS and CIR in univariate analyses.