Examples of mechanistically studied lncRNAs with roles during malignant hematopoiesis
| Name . | Function . | Mechanism . | Reference . |
|---|---|---|---|
| Recruiter lncRNAs | |||
| Xist | Directs and maintains female X chromosome dosage compensation | Scaffolds chromatin repressors as it spreads along its chromosome, silencing most of its genes and compacting it into a repressive compartment | 54 |
| LUNAR1 | Sustains oncogenic IGF1R activation | Recruits transcription machinery to an enhancer element shared with the IGF1R gene | 65 |
| Decoy lncRNAs | |||
| GAS5 | Modulates T-cell growth arrest and apoptosis | Sequesters the glucocorticoid receptor by binding to its DNA-binding domain via a hairpin structure that acts as a decoy glucocorticoid response element | 3,72,103 |
| FAS-AS1 | Suppresses production of soluble FAS receptor | Sequesters RBM5 from the Fas pre-mRNA to prevent its alternative splicing into an isoform encoding a soluble decoy receptor | 77 |
| Name . | Function . | Mechanism . | Reference . |
|---|---|---|---|
| Recruiter lncRNAs | |||
| Xist | Directs and maintains female X chromosome dosage compensation | Scaffolds chromatin repressors as it spreads along its chromosome, silencing most of its genes and compacting it into a repressive compartment | 54 |
| LUNAR1 | Sustains oncogenic IGF1R activation | Recruits transcription machinery to an enhancer element shared with the IGF1R gene | 65 |
| Decoy lncRNAs | |||
| GAS5 | Modulates T-cell growth arrest and apoptosis | Sequesters the glucocorticoid receptor by binding to its DNA-binding domain via a hairpin structure that acts as a decoy glucocorticoid response element | 3,72,103 |
| FAS-AS1 | Suppresses production of soluble FAS receptor | Sequesters RBM5 from the Fas pre-mRNA to prevent its alternative splicing into an isoform encoding a soluble decoy receptor | 77 |