The diagnostic workup and follow-up are summarized
| Time . | Planned analyses . |
|---|---|
| At clinical suspicion | Detailed investigation of the infections |
| Physical examination | |
| Laboratory tests: | |
| Full blood count | |
| Serum immunoglobulins (IgG, IgA, and IgM) | |
| Tetanus antitoxoid antibodies | |
| Lymphocyte subset absolute counts: CD3, CD4, CD8, CD19, and CD16 | |
| Cultures of sputum or nose-pharyngeal suction secretion | |
| Bone marrow aspirate | |
| At diagnosis | Laboratory tests: |
| Full blood count | |
| Serum immunoglobulins (IgG, IgA, and IgM) | |
| Extended T- and B-lymphocyte subsets (absolute counts): CD3; CD4; CD8; CD19; CD16; naïve and memory T cells; naïve, memory, and switched memory B cells | |
| Response to booster vaccine if antitoxoid antibodies unprotective | |
| Full blood count during acute infection to confirm normalization of the neutrophil count | |
| If suspected skin/anogenital lesions, consider a dermatologist evaluation and viral DNA analysis. | |
| If history of recurrent pulmonary infections, consider a pulmonologist evaluation and chest computed tomography (CT) scan. | |
| Every 6 mo | Physical examination |
| Consider a dermatologist and/or pulmonologist evaluation | |
| Pulmonary functional tests | |
| Laboratory tests: | |
| Full blood count* | |
| Serum immunoglobulins (IgG, IgA, and IgM)† | |
| Lymphocyte subsets (CD3, CD4, CD8, and CD19) | |
| Culture of sputum or nose-pharyngeal suction secretion | |
| Chest CT scan (on the basis of clinical manifestations) |
| Time . | Planned analyses . |
|---|---|
| At clinical suspicion | Detailed investigation of the infections |
| Physical examination | |
| Laboratory tests: | |
| Full blood count | |
| Serum immunoglobulins (IgG, IgA, and IgM) | |
| Tetanus antitoxoid antibodies | |
| Lymphocyte subset absolute counts: CD3, CD4, CD8, CD19, and CD16 | |
| Cultures of sputum or nose-pharyngeal suction secretion | |
| Bone marrow aspirate | |
| At diagnosis | Laboratory tests: |
| Full blood count | |
| Serum immunoglobulins (IgG, IgA, and IgM) | |
| Extended T- and B-lymphocyte subsets (absolute counts): CD3; CD4; CD8; CD19; CD16; naïve and memory T cells; naïve, memory, and switched memory B cells | |
| Response to booster vaccine if antitoxoid antibodies unprotective | |
| Full blood count during acute infection to confirm normalization of the neutrophil count | |
| If suspected skin/anogenital lesions, consider a dermatologist evaluation and viral DNA analysis. | |
| If history of recurrent pulmonary infections, consider a pulmonologist evaluation and chest computed tomography (CT) scan. | |
| Every 6 mo | Physical examination |
| Consider a dermatologist and/or pulmonologist evaluation | |
| Pulmonary functional tests | |
| Laboratory tests: | |
| Full blood count* | |
| Serum immunoglobulins (IgG, IgA, and IgM)† | |
| Lymphocyte subsets (CD3, CD4, CD8, and CD19) | |
| Culture of sputum or nose-pharyngeal suction secretion | |
| Chest CT scan (on the basis of clinical manifestations) |