Characteristics of peripheral blood of HNF1A+/+, HNF1A+/−, and HNF1A−/− mice
| Genotype . | HNF1A+/+, n = 7 . | HNF1A+/−, n = 7 . | HNF1A−/−, n = 7 . |
|---|---|---|---|
| HCT, % | 57.4 ± 1.5 | 50.0 ± 1.1††† | 48.3 ± 0.9*** |
| HGB, g/dL | 16.7 ± 0.5 | 16.2 ± 0.4 | 14.0 ± 0.3§§,*** |
| RBC, (×106)/µL blood (including reticulocytes) | 10.7 ± 0.2 | 11.1 ± 0.4 | 10.4 ± 0.3 |
| MCV, µm3 | 53.7 ± 0.5 | 51.6 ± 1.2 | 46.7 ± 1.2§,** |
| MCH, pg | 15.7 ± 0.2 | 14.6 ± 0.4 | 13.6 ± 0.4** |
| MCHC, g/dL | 29.1 ± 0.3 | 28.3 ± 0.3 | 29.0 ± 0.4 |
| RDW, % | 11.5 ± 0.2 | 12.0 ± 0.2 | 15.6 ± 0.3§§§,*** |
| Genotype . | HNF1A+/+, n = 7 . | HNF1A+/−, n = 7 . | HNF1A−/−, n = 7 . |
|---|---|---|---|
| HCT, % | 57.4 ± 1.5 | 50.0 ± 1.1††† | 48.3 ± 0.9*** |
| HGB, g/dL | 16.7 ± 0.5 | 16.2 ± 0.4 | 14.0 ± 0.3§§,*** |
| RBC, (×106)/µL blood (including reticulocytes) | 10.7 ± 0.2 | 11.1 ± 0.4 | 10.4 ± 0.3 |
| MCV, µm3 | 53.7 ± 0.5 | 51.6 ± 1.2 | 46.7 ± 1.2§,** |
| MCH, pg | 15.7 ± 0.2 | 14.6 ± 0.4 | 13.6 ± 0.4** |
| MCHC, g/dL | 29.1 ± 0.3 | 28.3 ± 0.3 | 29.0 ± 0.4 |
| RDW, % | 11.5 ± 0.2 | 12.0 ± 0.2 | 15.6 ± 0.3§§§,*** |
Data are presented as mean ± standard error of the mean (SEM). Age and sex were for HNF1A+/+ (161 ± 31 days; female [n = 5], male [n = 2]), HNF1A+/− (158 ± 24 days; female [n = 3], male [n = 4]), and HNF1A−/− mice (164 ± 31 days; female [n = 5], male [n = 2]).
MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, MCH concentration; RDW, red cell distribution width.
P < .01 and ***P < .001 for HNF1A+/+ vs HNF1A−/−, †††P < .001 for HNF1A+/+ vs HNF1A+/−, and §P < .05, §§P < .01, and §§§P < .001 for HNF1A+/− vs HNF1A−/− (1-way ANOVA followed by Tukey post hoc analysis).