Gene expression in livers of HNF1A+/+ and HNF1A−/− mice
| Gene . | HNF1A+/+ ΔCT, n = 3 . | HNF1A−/− ΔCT, n = 3 . | x-fold . |
|---|---|---|---|
| Sphk2 | 4.76 ± 0.23 | 5.61 ± 0.21 | 0.58 ± 0.09* |
| Sphk1 | 9.95 ± 0.67 | 8.87 ± 0.28 | 2.31 ± 0.41 |
| Ormdl1 | 4.50 ± 0.15 | 5.16 ± 0.18 | 0.66 ± 0.08* |
| Asah2 | 6.62 ± 0.15 | 5.72 ± 0.23 | 1.99 ± 0.29* |
| Cers5 | 7.51 ± 0.14 | 6.72 ± 0.19 | 1.81 ± 0.24* |
| Sgpp2 | 4.02 ± 0.31 | 4.59 ± 0.14 | 0.69 ± 0.07 |
| Sgpp1 | 18.06 ± 0.43 | 17.0 ± 0.40 | 2.59 ± 0.84 |
| Spns2 | 8.79 ± 0.26 | 8.29 ± 0.23 | 1.50 ± 0.25 |
| Asah1 | 3.75 ± 0.36 | 3.43 ± 0.13 | 1.28 ± 0.12 |
| Scarb1 | 2.24 ± 0.34 | 2.36 ± 0.27 | 0.99 ± 0.16 |
| Cers2 | 1.43 ± 0.15 | 2.36 ± 0.15 | 0.54 ± 0.05 |
| Smpd2 | 5.40 ± 0.15 | 5.67 ± 0.14 | 0.85 ± 0.08 |
| Smpd1 | 4.13 ± 0.12 | 4.19 ± 0.12 | 0.98 ± 0.08 |
| Sgms1 | 5.01 ± 0.17 | 4.87 ± 0.07 | 1.10 ± 0.05 |
| Sgms2 | 7.64 ± 0.21 | 8.03 ± 0.18 | 0.79 ± 0.10 |
| Spt | 4.82 ± 0.29 | 4.88 ± 0.12 | 0.98 ± 0.09 |
| Cers4 | 6.17 ± 0.28 | 6.67 ± 0.06 | 0.71 ± 0.03 |
| Nogo-A | 12.40 ± 1.09 | 14.25 ± 0.10 | 0.28 ± 0.02 |
| Nogo-B1 | 5.63 ± 0.36 | 5.21 ± 0.17 | 1.38 ± 0.15 |
| Gene . | HNF1A+/+ ΔCT, n = 3 . | HNF1A−/− ΔCT, n = 3 . | x-fold . |
|---|---|---|---|
| Sphk2 | 4.76 ± 0.23 | 5.61 ± 0.21 | 0.58 ± 0.09* |
| Sphk1 | 9.95 ± 0.67 | 8.87 ± 0.28 | 2.31 ± 0.41 |
| Ormdl1 | 4.50 ± 0.15 | 5.16 ± 0.18 | 0.66 ± 0.08* |
| Asah2 | 6.62 ± 0.15 | 5.72 ± 0.23 | 1.99 ± 0.29* |
| Cers5 | 7.51 ± 0.14 | 6.72 ± 0.19 | 1.81 ± 0.24* |
| Sgpp2 | 4.02 ± 0.31 | 4.59 ± 0.14 | 0.69 ± 0.07 |
| Sgpp1 | 18.06 ± 0.43 | 17.0 ± 0.40 | 2.59 ± 0.84 |
| Spns2 | 8.79 ± 0.26 | 8.29 ± 0.23 | 1.50 ± 0.25 |
| Asah1 | 3.75 ± 0.36 | 3.43 ± 0.13 | 1.28 ± 0.12 |
| Scarb1 | 2.24 ± 0.34 | 2.36 ± 0.27 | 0.99 ± 0.16 |
| Cers2 | 1.43 ± 0.15 | 2.36 ± 0.15 | 0.54 ± 0.05 |
| Smpd2 | 5.40 ± 0.15 | 5.67 ± 0.14 | 0.85 ± 0.08 |
| Smpd1 | 4.13 ± 0.12 | 4.19 ± 0.12 | 0.98 ± 0.08 |
| Sgms1 | 5.01 ± 0.17 | 4.87 ± 0.07 | 1.10 ± 0.05 |
| Sgms2 | 7.64 ± 0.21 | 8.03 ± 0.18 | 0.79 ± 0.10 |
| Spt | 4.82 ± 0.29 | 4.88 ± 0.12 | 0.98 ± 0.09 |
| Cers4 | 6.17 ± 0.28 | 6.67 ± 0.06 | 0.71 ± 0.03 |
| Nogo-A | 12.40 ± 1.09 | 14.25 ± 0.10 | 0.28 ± 0.02 |
| Nogo-B1 | 5.63 ± 0.36 | 5.21 ± 0.17 | 1.38 ± 0.15 |
Gene expression was measured by real-time PCR. Data are presented as ∆CT (mean of n = 3) and x-fold (ratio of the 2 means) and are normalized to Rn18s.
CT, cycle threshold.
P < .05 for HNF1A+/+ vs HNF1A−/−.