Multivariable Cox models for endpoints stratified by iciHHV-6 status
| Endpoint . | HCT recipient–donor iciHHV-6 status . | |||
|---|---|---|---|---|
| R−/D− (n=4232) . | R+/D− (n=47) . | R−/D+ (n=27) . | R+/D+ (n=13) . | |
| Acute GVHD, grades 2-4* | Ref | 1.7 (1.2-2.3)† | 1.9 (1.3-2.8)‡ | 0.9 (0.5-1.7) |
| Acute GVHD, grades 3-4¶ | Ref | 0.7 (0.3-1.4) | 1.8 (0.9-3.4) | 0.6 (0.2-2.5) |
| Chronic GVHD, 1 y§ | Ref | 1.0 (0.7-1.6) | 1.4 (0.9-2.2) | 2.1 (1.0-4.5) |
| CMV viremia, any‖ | Ref | 1.7 (1.1-2.6)** | 1.4 (0.8-2.3) | 1.0 (0.5-2.2) |
| CMV viremia, high-level†† | Ref | 3.1 (1.7-5.8)‡ | 1.9 (0.9-4.0) | 0.5 (0.07-3.7) |
| Overall mortality, 100 d‡‡ | Ref | 1.2 (0.6-2.5) | 0.5 (0.2-1.5) | 1.6 (0.5-4.9) |
| Overall mortality, 5 y¶¶ | Ref | 0.8 (0.5-1.3) | 0.8 (0.4-1.5) | 1.9 (0.8-4.2) |
| NRM, 1 y§§ | Ref | 0.8 (0.4-1.5) | 0.8 (0.4-1.6) | 1.5 (0.6-3.9) |
| Endpoint . | HCT recipient–donor iciHHV-6 status . | |||
|---|---|---|---|---|
| R−/D− (n=4232) . | R+/D− (n=47) . | R−/D+ (n=27) . | R+/D+ (n=13) . | |
| Acute GVHD, grades 2-4* | Ref | 1.7 (1.2-2.3)† | 1.9 (1.3-2.8)‡ | 0.9 (0.5-1.7) |
| Acute GVHD, grades 3-4¶ | Ref | 0.7 (0.3-1.4) | 1.8 (0.9-3.4) | 0.6 (0.2-2.5) |
| Chronic GVHD, 1 y§ | Ref | 1.0 (0.7-1.6) | 1.4 (0.9-2.2) | 2.1 (1.0-4.5) |
| CMV viremia, any‖ | Ref | 1.7 (1.1-2.6)** | 1.4 (0.8-2.3) | 1.0 (0.5-2.2) |
| CMV viremia, high-level†† | Ref | 3.1 (1.7-5.8)‡ | 1.9 (0.9-4.0) | 0.5 (0.07-3.7) |
| Overall mortality, 100 d‡‡ | Ref | 1.2 (0.6-2.5) | 0.5 (0.2-1.5) | 1.6 (0.5-4.9) |
| Overall mortality, 5 y¶¶ | Ref | 0.8 (0.5-1.3) | 0.8 (0.4-1.5) | 1.9 (0.8-4.2) |
| NRM, 1 y§§ | Ref | 0.8 (0.4-1.5) | 0.8 (0.4-1.6) | 1.5 (0.6-3.9) |
Data are presented as adjusted hazard ratio (95% confidence interval).
R+ or R− indicates recipient positive or negative for iciHHV-6; D+ or D−, donor positive or negative for iciHHV-6; GVHD, graft versus host disease.
The R−/D− group excluded 50 patients missing acute GVHD data. Adjusted for conditioning regimen, degree of HLA match, donor relation, and transplant year.
P < .01.
P < .001.
Adjusted for degree of HLA match, donor relation, and transplant year.
Adjusted for age, underling disease risk, conditioning regimen, degree of HLA match, donor relation, conditioning regimen, and transplant year.
Adjusted for age, recipient or donor CMV seropositive, degree of HLA match, and transplant year.
P < .05
Adjusted for age, recipient or donor CMV seropositive, degree of HLA match, transplant year, and acute GVHD grades 3-4.
No individuals were lost to follow up within the first 100 d. Models adjusted for age, recipient or donor CMV seropositive, underlying disease risk, degree of HLA match, donor relation, transplant year and acute GVHD grades 3-4.
Only individuals living past 100 d were included in this model. Adjusted for conditioning regimen, degree of HLA match, donor relation, and transplant year.
Adjusted for age, recipient or donor CMV seropositive, underlying disease risk, degree of HLA match, degree of HLA match, donor relation, transplant year, and acute GVHD grades 3-4.