Table 2.

Genome-wide burden test for association of mutant genes with clonal hematopoiesis

Mutation impact and gene symbolNumber of nonoutliers with mutation in gene*Number of WGS outliers with mutation in gene†P value‡OR
High     
 TET2 10 57 7.1 × 10−42 41.68 
 DNMT3A 6 38 9.0 × 10−29 45.65 
 ASXL1 2 18 7.0 × 10−15 64.04 
 PPM1D 3 15 1.4 × 10−11 35.48 
 ZNF318 5 8 4.1 × 10−5 11.30 
Moderate     
 DNMT3A 33 68 5.1 × 10−38 15.16 
 TET2 12 33 6.4 × 10−21 19.76 
 ATM 45 23 3.9 × 10−6 3.63 
 SRSF2 0 5 3.0 × 10−5 Inf 
 KPNA7 106 34 9.2 × 10−5 2.29 
 MTA2 4 7 9.6 × 10−5 12.35 
High and moderate 
 DNMT3A 39 105 6.6 × 10−64 20.36 
 TET2 21 85 7.8 × 10−58 30.18 
 ASXL1 27 23 5.0 × 10−9 6.07 
 PPM1D 16 16 2.6 × 10−7 7.09 
 SRSF2 0 5 3.0 × 10−5 Inf 
 PRKCG 5 8 4.1 × 10−5 11.30 
 ATM 59 24 6.3 × 10−5 2.89 
 MTA2 4 7 9.6 × 10−5 12.35 
Mutation impact and gene symbolNumber of nonoutliers with mutation in gene*Number of WGS outliers with mutation in gene†P value‡OR
High     
 TET2 10 57 7.1 × 10−42 41.68 
 DNMT3A 6 38 9.0 × 10−29 45.65 
 ASXL1 2 18 7.0 × 10−15 64.04 
 PPM1D 3 15 1.4 × 10−11 35.48 
 ZNF318 5 8 4.1 × 10−5 11.30 
Moderate     
 DNMT3A 33 68 5.1 × 10−38 15.16 
 TET2 12 33 6.4 × 10−21 19.76 
 ATM 45 23 3.9 × 10−6 3.63 
 SRSF2 0 5 3.0 × 10−5 Inf 
 KPNA7 106 34 9.2 × 10−5 2.29 
 MTA2 4 7 9.6 × 10−5 12.35 
High and moderate 
 DNMT3A 39 105 6.6 × 10−64 20.36 
 TET2 21 85 7.8 × 10−58 30.18 
 ASXL1 27 23 5.0 × 10−9 6.07 
 PPM1D 16 16 2.6 × 10−7 7.09 
 SRSF2 0 5 3.0 × 10−5 Inf 
 PRKCG 5 8 4.1 × 10−5 11.30 
 ATM 59 24 6.3 × 10−5 2.89 
 MTA2 4 7 9.6 × 10−5 12.35 

Data down to P = .01 are shown in supplemental Table 5.

*

Total number of non–WGS-outliers n = 9859.

†

Total number of WGS-outliers n = 1403.

‡

Fisher's exact test.

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