Body iron indices after tIO treatment or iron-rich diet
| . | Iron-free diet . | Iron-rich diet . | ||||
|---|---|---|---|---|---|---|
| Time (weeks) . | IA . | IO . | Time (months) . | Control . | IO . | |
| Serum iron, μmol/L | 1 | 22.2 ± 1.6 | 42.1 ± 4.4*** | 1 | 30.6 ± 3.2 | 48.5 ± 1.4* |
| 2 | 25.9 ± 7.2 | 45.8 ± 13.1** | ||||
| 4 | 29.8 ± 1.6 | 48.6 ± 3.5*** | ||||
| TIBC, μmol/L | 1 | 49.1 ± 1.4 | 58.0 ± 5.8* | 1 | 49.2 ± 1.8 | 43.7 ± 3.0 |
| 2 | 52.1 ± 2.9 | 63.3 ± 6.0*** | ||||
| 4 | 51.9 ± 3.4 | 97.7 ± 6.9*** | ||||
| TS, % | 1 | 30.1 ± 2.4 | 62.4 ± 2.3*** | 1 | 83.8 ± 8.7 | 113.3 ± 7.6* |
| 2 | 38.0 ± 9.3 | 71.2 ± 14.5*** | ||||
| 4 | 43.9 ± 3.6 | 99.5 ± 0.3*** | ||||
| Serum ferritin, μg/mL | 1 | 1.4 ± 0.4 | 3.4 ± 1.5** | 1 | 0.7 ± 0.1 | 1.3 ± 0.1** |
| 2 | 1.2 ± 0.2 | 3.9 ± 0.6*** | ||||
| 4 | 1.1 ± 0.1 | 9.6 ± 2.1*** | ||||
| Serum TNF-α, pg/mL | 1 | 1.3 ± 0.9 | 11.3 ± 4.9* | 1 | 2.3 ± 1.1 | 22.3 ± 1.8** |
| 2 | 1.3 ± 0.3 | 16.3 ± 7.8* | ||||
| 4 | 2.1 ± 1.3 | 16.2 ± 8.6* | ||||
| Serum IL-6, pg/mL | 1 | 7.3 ± 3.0 | 9.5 ± 2.4 | 1 | 12.1 ± 1.9 | 29.9 ± 4.1** |
| 2 | 6.9 ± 2.8 | 12.2 ± 1.7* | ||||
| 4 | 5.6 ± 1.2 | 9.6 ± 1.8** | ||||
| Liver iron, μg/g | 1 | 102.2 ± 23.5 | 1257 ± 253*** | 1 | 118.8 ± 41.0 | 362.3 ± 102.6*** |
| 2 | 101.7 ± 32.2 | 1760 ± 259*** | ||||
| 4 | 116.6 ± 21.6 | 2537 ± 712*** | ||||
| . | Iron-free diet . | Iron-rich diet . | ||||
|---|---|---|---|---|---|---|
| Time (weeks) . | IA . | IO . | Time (months) . | Control . | IO . | |
| Serum iron, μmol/L | 1 | 22.2 ± 1.6 | 42.1 ± 4.4*** | 1 | 30.6 ± 3.2 | 48.5 ± 1.4* |
| 2 | 25.9 ± 7.2 | 45.8 ± 13.1** | ||||
| 4 | 29.8 ± 1.6 | 48.6 ± 3.5*** | ||||
| TIBC, μmol/L | 1 | 49.1 ± 1.4 | 58.0 ± 5.8* | 1 | 49.2 ± 1.8 | 43.7 ± 3.0 |
| 2 | 52.1 ± 2.9 | 63.3 ± 6.0*** | ||||
| 4 | 51.9 ± 3.4 | 97.7 ± 6.9*** | ||||
| TS, % | 1 | 30.1 ± 2.4 | 62.4 ± 2.3*** | 1 | 83.8 ± 8.7 | 113.3 ± 7.6* |
| 2 | 38.0 ± 9.3 | 71.2 ± 14.5*** | ||||
| 4 | 43.9 ± 3.6 | 99.5 ± 0.3*** | ||||
| Serum ferritin, μg/mL | 1 | 1.4 ± 0.4 | 3.4 ± 1.5** | 1 | 0.7 ± 0.1 | 1.3 ± 0.1** |
| 2 | 1.2 ± 0.2 | 3.9 ± 0.6*** | ||||
| 4 | 1.1 ± 0.1 | 9.6 ± 2.1*** | ||||
| Serum TNF-α, pg/mL | 1 | 1.3 ± 0.9 | 11.3 ± 4.9* | 1 | 2.3 ± 1.1 | 22.3 ± 1.8** |
| 2 | 1.3 ± 0.3 | 16.3 ± 7.8* | ||||
| 4 | 2.1 ± 1.3 | 16.2 ± 8.6* | ||||
| Serum IL-6, pg/mL | 1 | 7.3 ± 3.0 | 9.5 ± 2.4 | 1 | 12.1 ± 1.9 | 29.9 ± 4.1** |
| 2 | 6.9 ± 2.8 | 12.2 ± 1.7* | ||||
| 4 | 5.6 ± 1.2 | 9.6 ± 1.8** | ||||
| Liver iron, μg/g | 1 | 102.2 ± 23.5 | 1257 ± 253*** | 1 | 118.8 ± 41.0 | 362.3 ± 102.6*** |
| 2 | 101.7 ± 32.2 | 1760 ± 259*** | ||||
| 4 | 116.6 ± 21.6 | 2537 ± 712*** | ||||
Data are presented as mean ± SD (N = 6).
TIBC, total iron-binding capacity; TS, transferrin saturation.
P < .05; **P < .01; ***P < .001 vs IA.