Recommended clinical assessments for patients with germ line genetic predisposition to hematologic malignancies
| . | After initial diagnosis of inherited predisposition . | At clinical follow-up . |
|---|---|---|
| Consider expert consultation or referral to specialized center | √ | Continued consultation as needed |
| Genetic counseling with certified genetic counselor trained in inherited hematopoietic malignancies | √ | As needed |
| Update personal/family history | √ | √ |
| Physical examination | √ | √ |
| CBC with white blood cell differential and microscopy review for dysplasias | √ | √ |
| Bone marrow biopsy with cytogenetic/FISH and molecular analysis | √ | Consider annually or when abnormalities develop on CBC |
| HLA typing and referral to allogeneic stem cell transplant center | If significant dysplasia or other indications of malignancy exist at baseline | Increasing dysplasia or other indications of malignancy |
| . | After initial diagnosis of inherited predisposition . | At clinical follow-up . |
|---|---|---|
| Consider expert consultation or referral to specialized center | √ | Continued consultation as needed |
| Genetic counseling with certified genetic counselor trained in inherited hematopoietic malignancies | √ | As needed |
| Update personal/family history | √ | √ |
| Physical examination | √ | √ |
| CBC with white blood cell differential and microscopy review for dysplasias | √ | √ |
| Bone marrow biopsy with cytogenetic/FISH and molecular analysis | √ | Consider annually or when abnormalities develop on CBC |
| HLA typing and referral to allogeneic stem cell transplant center | If significant dysplasia or other indications of malignancy exist at baseline | Increasing dysplasia or other indications of malignancy |
CBC, complete blood count; FISH, fluorescence in situ hybridization.