Laboratory response data
| Response level . | Increase in Hb level . | Highest Hb level posttherapy . | Decrease in total IgM concentration . | CA titer after therapy/CA titer before therapy . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median, g/dL . | Range, g/dL . | P . | Median, g/dL . | Range, g/dL . | Median, % of baseline . | Range, % of baseline . | P . | Median ratio . | P . | |
| CR | 4.4 | 0.2-11.8 | <.001 | 14.2 | 13.0-16.8 | 76 | 52-95 | <.001 | 0.000 | .01 |
| PR | 3.9 | 0.0-7.6 | <.001 | 12.5 | 10.0-15.0 | 74 | 37-96 | .02 | 0.250 | NS |
| NR | 0.0 | −2.5 to 1.6 | NS | 10.5 | 7.4-14.9 | 55 | −23 to 74 | .01 | 1.000 | NS |
| All patients | 3.7 | −2.5 to 11.8 | <.001 | 13.2 | 7.4-16.8 | 67 | −23 to 96 | .001 | 0.125 | .05 |
| Response level . | Increase in Hb level . | Highest Hb level posttherapy . | Decrease in total IgM concentration . | CA titer after therapy/CA titer before therapy . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median, g/dL . | Range, g/dL . | P . | Median, g/dL . | Range, g/dL . | Median, % of baseline . | Range, % of baseline . | P . | Median ratio . | P . | |
| CR | 4.4 | 0.2-11.8 | <.001 | 14.2 | 13.0-16.8 | 76 | 52-95 | <.001 | 0.000 | .01 |
| PR | 3.9 | 0.0-7.6 | <.001 | 12.5 | 10.0-15.0 | 74 | 37-96 | .02 | 0.250 | NS |
| NR | 0.0 | −2.5 to 1.6 | NS | 10.5 | 7.4-14.9 | 55 | −23 to 74 | .01 | 1.000 | NS |
| All patients | 3.7 | −2.5 to 11.8 | <.001 | 13.2 | 7.4-16.8 | 67 | −23 to 96 | .001 | 0.125 | .05 |
Seven patients with hemolysis without anemia were included because of circulatory symptoms requiring therapy, which explains the lower range of Hb level increase among the responders and the higher range of posttherapy Hb levels among the nonresponders. P values indicate statistical significance of changes.
NS, not significant.