Summary of AEs
| Event, n (%) . | Patients who received idelalisib as the last prior BCRi . | ||
|---|---|---|---|
| Main cohort (n = 21) . | Expansion cohort (n = 15) . | All patients (N = 36) . | |
| Any grade AE in 20% or more of all patients | |||
| All reported AEs | 21 (100) | 15 (100) | 36 (100) |
| Neutropenia* | 11 (52) | 9 (60) | 20 (56) |
| Diarrhea | 9 (43) | 6 (40) | 15 (42) |
| Upper respiratory tract infection | 6 (29) | 8 (53) | 14 (39) |
| Thrombocytopenia† | 7 (33) | 6 (40) | 13 (36) |
| Nausea | 6 (29) | 5 (33) | 11 (31) |
| Fatigue | 6 (29) | 4 (27) | 10 (28) |
| Rash | 6 (29) | 2 (13) | 8 (22) |
| Anemia | 4 (19) | 4 (27) | 8 (22) |
| Cough | 4 (19) | 4 (27) | 8 (22) |
| Grade 3 or 4 AEs in 10% or more of all patients | |||
| All reported grade 3 or 4 AEs | 17 (81) | 10 (67) | 27 (75) |
| Neutropenia* | 10 (48) | 8 (53) | 18 (50) |
| Thrombocytopenia† | 6 (29) | 3 (20) | 9 (25) |
| Anemia | 3 (14) | 3 (20) | 6 (17) |
| Hypokalemia | 1 (5) | 3 (20) | 4 (11) |
| Serious AEs in 5% or more of all patients | |||
| All serious AES | 10 (48) | 5 (33) | 15 (42) |
| Pneumonia | 2 (10) | 0 | 2 (6) |
| Cholecystitis or cholecystitis acute | 2 (10) | 0 | 2 (6) |
| Event, n (%) . | Patients who received idelalisib as the last prior BCRi . | ||
|---|---|---|---|
| Main cohort (n = 21) . | Expansion cohort (n = 15) . | All patients (N = 36) . | |
| Any grade AE in 20% or more of all patients | |||
| All reported AEs | 21 (100) | 15 (100) | 36 (100) |
| Neutropenia* | 11 (52) | 9 (60) | 20 (56) |
| Diarrhea | 9 (43) | 6 (40) | 15 (42) |
| Upper respiratory tract infection | 6 (29) | 8 (53) | 14 (39) |
| Thrombocytopenia† | 7 (33) | 6 (40) | 13 (36) |
| Nausea | 6 (29) | 5 (33) | 11 (31) |
| Fatigue | 6 (29) | 4 (27) | 10 (28) |
| Rash | 6 (29) | 2 (13) | 8 (22) |
| Anemia | 4 (19) | 4 (27) | 8 (22) |
| Cough | 4 (19) | 4 (27) | 8 (22) |
| Grade 3 or 4 AEs in 10% or more of all patients | |||
| All reported grade 3 or 4 AEs | 17 (81) | 10 (67) | 27 (75) |
| Neutropenia* | 10 (48) | 8 (53) | 18 (50) |
| Thrombocytopenia† | 6 (29) | 3 (20) | 9 (25) |
| Anemia | 3 (14) | 3 (20) | 6 (17) |
| Hypokalemia | 1 (5) | 3 (20) | 4 (11) |
| Serious AEs in 5% or more of all patients | |||
| All serious AES | 10 (48) | 5 (33) | 15 (42) |
| Pneumonia | 2 (10) | 0 | 2 (6) |
| Cholecystitis or cholecystitis acute | 2 (10) | 0 | 2 (6) |