Clinical and laboratory findings that might herald malignant progression
| Clinical signs/symptoms (unexplained) . |
|---|
| 1. Anemia |
| 2. Cardiomyopathy (restrictive) |
| 3. Diarrhea |
| 4. Fracture |
| 5. Hepatomegaly |
| 6. Hypercalcemia |
| 7. Hyperviscosity (in the setting of IgM M-protein) |
| 8. Intestinal pseudo-obstruction |
| 9. Lytic lesion |
| 10. Macroglossia |
| 11. Nephrotic syndrome |
| 12. Neuropathy (autonomic, sensory, or motor) |
| 13. Purpura |
| 14. Renal insufficiency |
| Clinical signs/symptoms (unexplained) . |
|---|
| 1. Anemia |
| 2. Cardiomyopathy (restrictive) |
| 3. Diarrhea |
| 4. Fracture |
| 5. Hepatomegaly |
| 6. Hypercalcemia |
| 7. Hyperviscosity (in the setting of IgM M-protein) |
| 8. Intestinal pseudo-obstruction |
| 9. Lytic lesion |
| 10. Macroglossia |
| 11. Nephrotic syndrome |
| 12. Neuropathy (autonomic, sensory, or motor) |
| 13. Purpura |
| 14. Renal insufficiency |
| Monoclonal protein studies . |
|---|
| 1. Serum M-protein: IgG or IgA ≥3.0 g/dL |
| 2. Urine M-protein ≥ 500 mg in 24 h |
| 3. Serum κ or λ free light chain ≥100 mg/dL and involved/uninvolved FLC >100 |
| 4. 50% increase in serum monoclonal protein (absolute increase of ≥0.5 g/dL) |
| Monoclonal protein studies . |
|---|
| 1. Serum M-protein: IgG or IgA ≥3.0 g/dL |
| 2. Urine M-protein ≥ 500 mg in 24 h |
| 3. Serum κ or λ free light chain ≥100 mg/dL and involved/uninvolved FLC >100 |
| 4. 50% increase in serum monoclonal protein (absolute increase of ≥0.5 g/dL) |