Trials examining role of Fc fusion or PEGylation in prevention and eradication of inhibitors
| Trial . | Population . | Product . | Outcome . |
|---|---|---|---|
| INHIBIT | Previously untreated hemophilia A patients | Fc-rFVIII | Inhibitor formation T-regulatory cells |
| Adynovate PUP | Previously untreated hemophilia A patients | PEG-rFVIII | Inhibitor formation |
| VerITI-8 | Hemophilia A patients with high titer inhibitors | Fc-rFVIII | Induction of tolerance |
| Trial . | Population . | Product . | Outcome . |
|---|---|---|---|
| INHIBIT | Previously untreated hemophilia A patients | Fc-rFVIII | Inhibitor formation T-regulatory cells |
| Adynovate PUP | Previously untreated hemophilia A patients | PEG-rFVIII | Inhibitor formation |
| VerITI-8 | Hemophilia A patients with high titer inhibitors | Fc-rFVIII | Induction of tolerance |
INHIBIT, Hemophilia Inhibitor Prevention Trial; VerITI-8, A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment.