Structure–function correlates of TM
| Structure . | Residues . | Function/interaction . |
|---|---|---|
| Lectin-like domain | 1-154 | Inhibits neutrophil adhesion |
| Mediates cell–cell interactions via homotypic interactions | ||
| Binding site for HMGB1, Ley | ||
| Inhibits complement activation | ||
| Binding site for kringle 1-5 fragment of plasminogen and urokinase receptor | ||
| Binding site for fibronectin | ||
| Hydrophobic | 155-222 | — |
| EGF1-EGF2 | 223-304 | Binding site for HMGB1 required for its cleavage by thrombin |
| EGF3-EGF6 | 305-462 | Activation of proCPB2 |
| EGF4-EGF6 | 346-462 | Activation of PC |
| Thrombin neutralization by PCI | ||
| Mitogenic | ||
| EGF5-EGF6 | 387-462 | Thrombin-binding site (high affinity) |
| Inactivation of scu-PA (+CS) | ||
| Binding to GPCR15 on T cells | ||
| Anti-inflammatory (?) | ||
| EGF1-EGF6 | 223-462 | Mitogenic |
| Binding to CD14 | ||
| Ligand for EGFR1 | ||
| Chondroitin sulfate in serine-threonine–rich region | 463-495 | Thrombin-binding site (low affinity) |
| Enhances neutralization of single chain urokinase (scu-PA) | ||
| Enhances neutralization of thrombin by PCI and heparin-antithrombin | ||
| PF4 binding, which enhances activation of PC | ||
| Binding to CD14 | ||
| Binding to integrins, MAC-1, and LFA-1 | ||
| Transmembrane | 496-521 | Target for TM cleavage by rhomboid-like-2 serine protease |
| Cytoplasmic tail | 522-557 | Binding site for adaptor protein ezrin, which modulates the cytoskeleton |
| Site of threonine phosphorylation |
| Structure . | Residues . | Function/interaction . |
|---|---|---|
| Lectin-like domain | 1-154 | Inhibits neutrophil adhesion |
| Mediates cell–cell interactions via homotypic interactions | ||
| Binding site for HMGB1, Ley | ||
| Inhibits complement activation | ||
| Binding site for kringle 1-5 fragment of plasminogen and urokinase receptor | ||
| Binding site for fibronectin | ||
| Hydrophobic | 155-222 | — |
| EGF1-EGF2 | 223-304 | Binding site for HMGB1 required for its cleavage by thrombin |
| EGF3-EGF6 | 305-462 | Activation of proCPB2 |
| EGF4-EGF6 | 346-462 | Activation of PC |
| Thrombin neutralization by PCI | ||
| Mitogenic | ||
| EGF5-EGF6 | 387-462 | Thrombin-binding site (high affinity) |
| Inactivation of scu-PA (+CS) | ||
| Binding to GPCR15 on T cells | ||
| Anti-inflammatory (?) | ||
| EGF1-EGF6 | 223-462 | Mitogenic |
| Binding to CD14 | ||
| Ligand for EGFR1 | ||
| Chondroitin sulfate in serine-threonine–rich region | 463-495 | Thrombin-binding site (low affinity) |
| Enhances neutralization of single chain urokinase (scu-PA) | ||
| Enhances neutralization of thrombin by PCI and heparin-antithrombin | ||
| PF4 binding, which enhances activation of PC | ||
| Binding to CD14 | ||
| Binding to integrins, MAC-1, and LFA-1 | ||
| Transmembrane | 496-521 | Target for TM cleavage by rhomboid-like-2 serine protease |
| Cytoplasmic tail | 522-557 | Binding site for adaptor protein ezrin, which modulates the cytoskeleton |
| Site of threonine phosphorylation |
CS, chondroitin sulfate; PCI, protein C inhibitor; scu-PA, single chain urokinase.