Table 1.

Characteristics of aggressive B-cell lymphomas in the AYA population

BLDLBCLPMBCL
PediatricsAdultsPediatricsAdultsPediatricsAdults
NHL, % 50 15 40 
Gender M >> F M >> F M > F M > F M = F F >> M 
Cell of origin GCB Almost all GCB GCB > ABC ABC ↑ with age Thymic B cell 
Molecular features All MYC rearranged, some differences reported  MYC-R 10% No known differences 
Outcome EFS > 90% ↓ with ↑ age EFS > 90% EFS 70% EFS 70% EFS > 85% 
BLDLBCLPMBCL
PediatricsAdultsPediatricsAdultsPediatricsAdults
NHL, % 50 15 40 
Gender M >> F M >> F M > F M > F M = F F >> M 
Cell of origin GCB Almost all GCB GCB > ABC ABC ↑ with age Thymic B cell 
Molecular features All MYC rearranged, some differences reported  MYC-R 10% No known differences 
Outcome EFS > 90% ↓ with ↑ age EFS > 90% EFS 70% EFS 70% EFS > 85% 

F, female; M, male.

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