Table 2. Effect of Ro 31-8220 (3 × 10 −5... | American Society of Hematology

Table 2.

Effect of Ro 31-8220 (3 × 10⁻⁵ mol/L) and Staurosporine (10⁻⁷ mol/L) on Intracellular Calcium Transients Induced by Maximally Effective Concentrations of PAF, C5a, and LTB₄

	Intracellular Ca²⁺ Transient
	(area under the curve −nmol/L Ca²⁺ × second)
	Control	Ro 31-8220	Staurosporine (10⁻⁷ mol/L)
		(3 × 10⁻⁵ mol/L)
PAF (10⁻⁸ mol/L)	5.8 ± 1.2	0^*	4.4 ± 2.6
C5a (10⁻⁷ mol/L)	11.4 ± 1.8	60.5 ± 14.4^*	30.9 ± 2.1^†
LTB₄ (10⁻⁸ mol/L)	16.3 ± 6.4	37.9 ± 7.2^*	29.9 ± 6.0^†

	Intracellular Ca²⁺ Transient
	(area under the curve −nmol/L Ca²⁺ × second)
	Control	Ro 31-8220	Staurosporine (10⁻⁷ mol/L)
		(3 × 10⁻⁵ mol/L)
PAF (10⁻⁸ mol/L)	5.8 ± 1.2	0^*	4.4 ± 2.6
C5a (10⁻⁷ mol/L)	11.4 ± 1.8	60.5 ± 14.4^*	30.9 ± 2.1^†
LTB₄ (10⁻⁸ mol/L)	16.3 ± 6.4	37.9 ± 7.2^*	29.9 ± 6.0^†

Values are the mean ± SEM of three to four experiments.

P < .01 when compared with control values.

†

P < .05 when compared with control values.

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