Exon and Intron Organization of the LU Gene
| Exon . | Nucleotide Number* . | Amino Acid . | Exon Size (bp) . | Splice Acceptor Site Splice Donor Site . | Intron Size (bp) . | ||
|---|---|---|---|---|---|---|---|
| 1 | −23-82 | 1-27 | 105 | CCCAG/gtatggctcgggctg | >2,000 | ||
| 2 | 83-204 | 28-68 | 122 | gttgctctcttgcag/ATGCC | .... | TCCTT/gtgagtgcttggggc | ∼500 |
| 3 | 205-433 | 69-144 | 229 | gccccgcgcccacag/ACCGA | .... | GTTTG/gtaagtgtcctcggg | 85 |
| 4 | 434-504 | 145-168 | 71 | acgtctttttcacag/CAAAG | .... | AGGAG/gtacctctcgggtgg | ∼650 |
| 5 | 505-601 | 169-200 | 97 | ccgtgtctgcctcag/ATCGC | .... | CCCAG/gtgagcagcgcagga | 91 |
| 6 | 602-784 | 201-261 | 183 | cccgatctctcccag/AGGGC | .... | GCACT/gttgagtcttctggc | ∼500 |
| 7 | 785-921 | 262-307 | 137 | ctgcccttcccttag/ATCCC | .... | TTCAG/gtgacccacccaagg | 315 |
| 8 | 922-1,078 | 308-359 | 157 | tcccccgtctcccag/GATGA | .... | GGCCT/gtgagagccctgggt | ∼3,500 |
| 9 | 1,079-1,194 | 360-398 | 116 | tgtcccccactgcag/ATCTG | .... | CCAAG/gtgagagggagagga | 103 |
| 10 | 1,195-1,336 | 399-445 | 142 | ctctgcccttcccag/GACTC | .... | CCAAG/gttcagggggcaggg | 173 |
| 11 | 1,337-1,473 | 446-491 | 137 | ccccaccacctacag/GCTCG | .... | GCAGC/gtaagggaccttcct | 153 |
| 12 | 1,474-1,618 | 492-539 | 145 | tcggagcctccatag/CCCGC | .... | CGCCG/gtgagtgactgaggt | 91 |
| 13 | 1,619-1,763 | 540-588 | 145 | atcctgtccctgcag/TGAGC | .... | GCTCC/gtgagtggcctgcta | 977 |
| 14 | 1,764-1,881 | 589-627 | 118 | gcctcctccccccag/GCCGC | .... | ACGAG/gtgggtgagggcctg | 93 |
| 15 | 1,882-2,380 | 628 | 498 | ccatccgctccccag/TGCTG | .... |
| Exon . | Nucleotide Number* . | Amino Acid . | Exon Size (bp) . | Splice Acceptor Site Splice Donor Site . | Intron Size (bp) . | ||
|---|---|---|---|---|---|---|---|
| 1 | −23-82 | 1-27 | 105 | CCCAG/gtatggctcgggctg | >2,000 | ||
| 2 | 83-204 | 28-68 | 122 | gttgctctcttgcag/ATGCC | .... | TCCTT/gtgagtgcttggggc | ∼500 |
| 3 | 205-433 | 69-144 | 229 | gccccgcgcccacag/ACCGA | .... | GTTTG/gtaagtgtcctcggg | 85 |
| 4 | 434-504 | 145-168 | 71 | acgtctttttcacag/CAAAG | .... | AGGAG/gtacctctcgggtgg | ∼650 |
| 5 | 505-601 | 169-200 | 97 | ccgtgtctgcctcag/ATCGC | .... | CCCAG/gtgagcagcgcagga | 91 |
| 6 | 602-784 | 201-261 | 183 | cccgatctctcccag/AGGGC | .... | GCACT/gttgagtcttctggc | ∼500 |
| 7 | 785-921 | 262-307 | 137 | ctgcccttcccttag/ATCCC | .... | TTCAG/gtgacccacccaagg | 315 |
| 8 | 922-1,078 | 308-359 | 157 | tcccccgtctcccag/GATGA | .... | GGCCT/gtgagagccctgggt | ∼3,500 |
| 9 | 1,079-1,194 | 360-398 | 116 | tgtcccccactgcag/ATCTG | .... | CCAAG/gtgagagggagagga | 103 |
| 10 | 1,195-1,336 | 399-445 | 142 | ctctgcccttcccag/GACTC | .... | CCAAG/gttcagggggcaggg | 173 |
| 11 | 1,337-1,473 | 446-491 | 137 | ccccaccacctacag/GCTCG | .... | GCAGC/gtaagggaccttcct | 153 |
| 12 | 1,474-1,618 | 492-539 | 145 | tcggagcctccatag/CCCGC | .... | CGCCG/gtgagtgactgaggt | 91 |
| 13 | 1,619-1,763 | 540-588 | 145 | atcctgtccctgcag/TGAGC | .... | GCTCC/gtgagtggcctgcta | 977 |
| 14 | 1,764-1,881 | 589-627 | 118 | gcctcctccccccag/GCCGC | .... | ACGAG/gtgggtgagggcctg | 93 |
| 15 | 1,882-2,380 | 628 | 498 | ccatccgctccccag/TGCTG | .... |
Intron and exon sequences are shown in lowercase and uppercase, respectively. The 5′ donor gt and the 3′ acceptor ag are underlined.
+1 taken as the first nucleotide of the initiation codon in the cDNA sequence.